Results 1 to 10 of about 23,244 (239)

CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9

Biomedicines, 2023
Background: In many solid tumors, CD44 has been identified as a cancer stem cell marker as well as an important molecular in cancer progression and metastasis, making it attractive for potential therapeutic applications. However, our knowledge of the biological function and mechanism of CD44 in clear cell renal cell carcinoma (ccRCC) is limited ...
Wu Yaqian, Yimeng Song, Zonglong Wu
exaly   +5 more sources

A prognostic index model for assessing the prognosis of ccRCC patients by using the mRNA expression profiles of AIF1L, SERPINC1 and CES1 [PDF]

Journal of Men's Health, 2022
Background: Kidney carcinoma is a major cause of carcinoma-related death, with the prognosis for advanced or metastatic renal cell carcinoma still very poor.
Song Zheng, Zihao Chen, Jianhui Chen, Rong Liu, Mei Song, Angchao Ye, Shaoxing Zhu, Hua Wang, Zongping Wang, Fangyin Li, Jinhan Lou, Yaping Chen, Fang Fang, Chunmei Wen, Jing Zhang, Bilan Xue, He Wang, Jianmin Lou, Weizhong Cai, Yaoyao Wu, Yipeng Xu   +20 more
doaj   +1 more source

Identification of candidate biomarker EMP3 and its prognostic potential in clear cell renal cell carcinoma

Frontiers in Bioscience-Landmark, 2021
Background: Clear cell renal cell carcinoma (ccRCC) is considered the second most common urogenital tract carcinoma, plaguing patients worldwide due to its high incidence and resistance to treatment.
Qingyang Lv, Wen Xiao, Zhiyong Xiong, Jian Shi, Daojia Miao, Xiangui Meng, Hongwei Yuan, Hongmei Yang, Xiaoping Zhang   +8 more
doaj   +1 more source

MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis

Cancer Biology & Medicine, 2022
Objective: In various cancers, migration and invasion inhibitory protein (MIIP) is expressed at low level and is involved in cancer pathogenesis. Herein, we sought to explore the function of MIIP in clear cell renal cell carcinoma (ccRCC). Methods: CCK-8,
Fengqi Yan, Qinhao Wang, Mingyuan Xia, Yi Ru, Wei Hu, Guang Yan, Xin Xiong, Mei Zhang, Jiancai Wang, Qi Li, Bo Zhang, He Wang, Wei Lin, Guojun Wu, Xia Li   +14 more
doaj   +1 more source

Clinical utility of MCM2 and CD44 expression in clear cell renal cell carcinoma

Polish Journal of Pathology, 2021
Clear cell renal cell carcinoma (ccRCC) has an unpredictable clinical consequence even with the use of usual prognostic factors. To determine whether utilization of cell proliferation and cell adhesion by using MCM2 and CD44 immuno-expression could ...
Mariana F. Gayyed, Medhat M. Soliman, Maram El-Hussieny   +2 more
doaj   +1 more source

ccRCC is fundamentally a metabolic disorder [PDF]

Cell Cycle, 2014
Clear cell renal-cell carcinoma (ccRCC) represents the most common RCC subtype, being exceptionally resistant to therapy and responding poorly to radiotherapy, hormonal therapy and chemotherapy1; t...
Zaravinos, Apostolos, Constantinou-Deltas, Constantinos D., Zaravinos, Apostolos, Constantinou-Deltas, Constantinos D.   +3 more
openaire   +3 more sources

NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma

Cancer Biology & Therapy, 2023
In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression.
Jaclyn M. Kubala, Kristian B. Laursen, Ryan Schreiner, Ryan M. Williams, Johannes C. van der Mijn, Michael J. Crowley, Nigel P. Mongan, David M. Nanus, Daniel A. Heller, Lorraine J. Gudas   +9 more
doaj   +1 more source

MT1X is an oncogene and indicates prognosis in ccRCC

Bioscience Reports, 2022
Abstract The metallothionein 1 (MT1) family was previously shown to be involved in metal ion homeostasis, DNA damage, oxidative stress, and carcinogenesis. Our team’s previous study showed that MT1X is most closely associated with ccRCC. However, its role in clear cell RCC (ccRCC) remains unclear.
Yanpeng Ding, Jiayu Fang, Mengge Chen, Yulian Xu, Nuomin Liu, Sha Fang, Wenbin Xiang, Rui Chen, Chaoyan Wu, Haijun Yu   +9 more
openaire   +2 more sources

Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma

OncoImmunology, 2020
Metastatic clear cell renal cell carcinoma (mccRCC) benefits from several treatment options in the first-line setting with VEGFR inhibitors and/or immunotherapy including anti-PD-L1 or anti-PD1 agents.
Christopher Montemagno, Anais Hagege, Delphine Borchiellini, Brice Thamphya, Olivia Rastoin, Damien Ambrosetti, Juan Iovanna, Nathalie Rioux-Leclercq, Camillio Porta, Sylvie Negrier, Jean-Marc Ferrero, Emmanuel Chamorey, Gilles Pagès, Maeva Dufies   +13 more
doaj   +1 more source

circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis

Open Medicine, 2022
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancers. However, circ_DENND1B has not been studied yet. GSE100186 dataset was used for the level analysis of circ_DENND1B.
Chen Deqiang, Zhang Yanchun, Meng Liang, Lu Li, Meng Gaopei   +4 more
doaj   +1 more source