Results 41 to 50 of about 9,624 (181)

DOK1 facilitates the advancement of ccRCC

Journal of Cancer
Background: Renal cell carcinoma (RCC) is one of the most common human cancers. Clear cell renal cell carcinoma (ccRCC) is a major subtype of RCC. However, the molecular mechanisms underlying ccRCC oncogenesis require further investigation. Docking protein 1 (DOK1) is a putative tumor suppressor gene; however, its role in ccRCC remains unclear. Methods:
Xie, Wei, Zhang, Yuanfeng, Shu, Bian, Zhang, Zhechuan, Zhang, Ronggui   +4 more
openaire   +2 more sources

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC

Cell Metabolism, 2023
Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".
Cerise Tang, Amy X. Xie, Eric Minwei Liu, Fengshen Kuo, Minsoo Kim, Renzo G. DiNatale, Mahdi Golkaram, Ying-Bei Chen, Sounak Gupta, Robert J. Motzer, Paul Russo, Jonathan Coleman, Maria I. Carlo, Martin H. Voss, Ritesh R. Kotecha, Chung-Han Lee, Wesley Tansey, Nikolaus Schultz, A. Ari Hakimi, Ed Reznik   +19 more
openaire   +6 more sources

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

RhoB expression is downregulated in ccRCC tissues and cell lines.

, 2016
(A) RhoB protein expression was detected in surgical specimens of ccRCC and their corresponding adjacent non-tumorous tissues by western blot analysis.
Huijie Gong (2635267), Haigang Pang (431222), Donglai Shen (3158409), Shaoxi Niu (3158412), Yu Gao (69071), Peng Zhang (2071), Yu Zhang (12946), Xin Ma (37268), Xu Zhang (49484), Liangyou Gu (2212054), Weihao Chen (431221), Yang Fan (220863)   +11 more
core   +1 more source

Single-Cell Sequencing to Identify Six Heat Shock Protein (HSP) Genes-Mediated Progression Subtypes of Clear Cell Renal Cell Carcinoma

International Journal of General Medicine, 2021
Qinke Li, Maoqing Lu, Zhechuan Zhang, Ronggui Zhang Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Ronggui ZhangDepartment of Urology, The Second Affiliated ...
Li Q, Lu M, Zhang Z, Zhang R
doaj  

High Hepcidin expression predicts poor prognosis in patients with clear cell renal cell carcinoma

Diagnostic Pathology, 2022
Clear cell renal cell carcinoma (ccRCC) is a growing public health challenge worldwide. Hepcidin antimicrobial peptide (HAMP) is differentially expressed in various tumors. However, the roles and functions of HAMP in ccRCC remain unclear.
Yuting Tang, Shengdong Ge, Xiao Zheng, Jiejiao Zheng   +3 more
doaj   +1 more source

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

Distribution of GRP78 expression in ccRCC associated perinephric adipose tissue (N = 60) among different categories of ccRCC aggressiveness.

, 2019
Distribution of GRP78 expression in ccRCC associated perinephric adipose tissue (N = 60) among different categories of ccRCC aggressiveness.
Sharon Juliet Del Vecchio (6239654), Robert J. Ellis (668685), David W. Johnson (221347), Glenda C. Gobe (3630025), David A. Vesey (3234039), Armando Teixeira-Pinto (101747), Michael A. McGuckin (128370), Yeoungjee Cho (6239657), Kunyu Shen (6239651)   +8 more
core   +1 more source

DataSheet_5_Cuproptosis in ccRCC: key player in therapeutic and prognostic targets.zip

, 2023
BackgroundClassical biomarkers have been used to classify clear cell renal cell carcinoma (ccRCC) patients in a variety of ways, and emerging evidences have indicated that cuproptosis is closely related to mitochondrial metabolism, thereby accelerating ...
Shaohua He (13202703), Chao Qin (119135), Zhongwen Lu (10134056), Qiang Li (8118), Hongqi Chen (425987), Yang Lv (279176), Lu Yin (183747)   +6 more
core   +1 more source

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC

Cell Death & Disease, 2023
AbstractClear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is associated with poor prognosis. The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be expressed at low levels and frequently mutated in ccRCC.
Wei Xue, Wengang Jian, Yuyang Meng, Tengda Wang, Licheng Cai, Yongchun Yu, Yipeng Yu, Zhinan Xia, Cheng Zhang   +8 more
openaire   +3 more sources