Results 1 to 10 of about 57,100 (255)

HIF-2α drives osteoarthritis progression via suppression of the HDAC4-ATF4-CHOP signaling axis. [PDF]

PLoS ONE
Hypoxia-inducible factor-2α (HIF-2α) is a key regulator of cellular adaptation to hypoxia, but its role in osteoarthritis (OA) remains incompletely defined.
Pinpin Jiang, Hang Wang, Yujia Li, Yuanyu Zhang, Jingrui Huang, Yukun Xu, Dahai Rong, Danni Ruan, Yao Wang, Jie Yuan, Pengcui Li   +10 more
doaj   +2 more sources

The Effect of HIF-2α on the Development of Inflammation [PDF]

International Journal of Inflammation
Hypoxia-inducible factor-2α (HIF-2α), a key regulator of cellular adaptation to hypoxia, modulates cellular metabolism, allowing cells to survive under hypoxic conditions.
Jiarui Huang, Daohong Zhao
doaj   +2 more sources

Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer [PDF]

The Journal of Clinical Investigation
Resistance to HIF-2α inhibitors such as belzutifan underscores the need to better understand how HIF-2α is transcriptionally regulated in clear cell renal cell carcinoma (ccRCC).
Jun Fang, Jeremy M. Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A. Nathan, Ram Mani, James Brugarolas, Qing Zhang   +15 more
doaj   +2 more sources

T cell-specific HIF-2α attenuates colitis by antagonizing notch-driven Th2 differentiations [PDF]

Frontiers in Immunology
ObjectiveThe function of hypoxia-inducible factor-2α (HIF-2α) in ulcerative colitis pathogenesis is subject to ongoing debate, with conflicting reports indicating either disease-promoting or beneficial roles. This investigation was designed to define the
Ting Gao, Liangfeng Gao, Hui Zhang, Zaizhi Liu, Qing Zhu, Chunyan Wang, Song Zhang, Nan Feng   +7 more
doaj   +2 more sources

Reduced Circulating HIF‐1α, HIF‐2α, HIF‐3α, and VHL Levels in Patients With Pulmonary Arterial Hypertension [PDF]

Pulmonary Circulation
Pulmonary arterial hypertension (PAH) involves complex vascular remodeling. The hypoxia‐inducible factor (HIF) pathway is a central oxygen‐sensing mechanism, but its circulating profile in PAH is poorly defined.
Hasan Kan, Yakup Alsancak, Meltem Uyaner Kan, Emine Göktaş, Mustafa Çelik, Ahmet Seyfeddin Gürbüz, Mehmet Akif Düzenli   +6 more
doaj   +2 more sources

Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion.
Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K. Pasupulati, Simon S. Evers, Ian J. Sipula, Michael Jurczak, Randy J. Seeley, Yatrik M. Shah, Sadeesh K. Ramakrishnan   +8 more
doaj   +1 more source

Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell ProliferationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Hypoxia and hypoxia-inducible factors (HIFs) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation contributed significantly to nonalcoholic fatty liver disease progression in ...
Beatrice Foglia, Salvatore Sutti, Stefania Cannito, Chiara Rosso, Marina Maggiora, Riccardo Autelli, Erica Novo, Claudia Bocca, Gianmarco Villano, Naresh Naik Ramavath, Ramy Younes, Ignazia Tusa, Elisabetta Rovida, Patrizia Pontisso, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola   +16 more
doaj   +1 more source

The effects of hypoxia-inducible factors-1α and -2α and erythroferrone on hepcidin in patients with chronic kidney disease stages 3–5 and renal anemia

European Journal of Inflammation, 2022
Objective This study aimed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and erythroferrone (ERFE) on hepcidin in patients with chronic kidney disease (CKD) stages 3–5 and renal anemia.
Jianghuai Hong, Jingjing Lai, Xiaoying Chen, Yan Yan, Yanyan Hong, Hailun Ke, Jing Zheng   +6 more
doaj   +1 more source

Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon tetrachloride-induced liver fibrosis in mice [PDF]

PeerJ, 2023
Background The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon tetrachloride (CCl4).
Jianfang Ye, Jie Chen, Yun Li, Liao Sun, Hongyun Lu   +4 more
doaj   +2 more sources

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Molecular Cancer, 2017
Background Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor cells to adapt to the hypoxic ...
Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai, Tingbo Liang   +9 more
doaj   +1 more source