Results 21 to 30 of about 57,100 (255)

Trichostatin A destabilizes HIF-2α through a VHL-independent but proteasome-dependent pathway in cancer cell lines and tumor xenografts

Bangladesh Journal of Pharmacology, 2013
Histone deacetylase (HDACs) inhibitors are a new generation of anti-cancer agents. Little is known regarding the effect of HDAC inhibitors on HIF-2α.
Qingcheng Yang, Yuzhen Du, Dongdong Cheng, Zhichang Zhang, Xinhui Du   +4 more
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source

Hypoxia-inducible factor 2α overexpression in podocytes ameliorates lipid metabolism disorders in diabetic kidney disease by inhibiting S1P

Renal Failure
Background and aims: Lipid accumulation in podocytes is a major driver of diabetic kidney disease (DKD). Hypoxia-inducible factor 2α (HIF-2α) plays an important role in regulating metabolism.
Xue Yang, Qimeng Wang, Huibin Nie, Mingming Wang, Yinghui Wang, Shan Li, Qingzhen Liu, Gang Liu   +7 more
doaj   +1 more source

Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.

PLoS ONE, 2012
The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects.
Ruth E Schietke, Thomas Hackenbeck, Maxine Tran, Regina Günther, Bernd Klanke, Christina L Warnecke, Karl X Knaup, Deepa Shukla, Christian Rosenberger, Robert Koesters, Sebastian Bachmann, Peter Betz, Gunnar Schley, Johannes Schödel, Carsten Willam, Thomas Winkler, Kerstin Amann, Kai-Uwe Eckardt, Patrick Maxwell, Michael S Wiesener   +19 more
doaj   +1 more source

Hypoxia increases the expressions of HIF-1α and HIF-2α.

, 2013
(A) In comparison to the cells cultivated at 20% O2, the cells cultivated at 7% O2 show higher levels of HIF-1α and HIF-2α, and the cells cultivated at 1% O2 show the highest levels of HIF-1α and HIF-2α by both RT-PCR and immunoblotting.
Yuanyuan Ma (280707), Dongming Liang (280708), Zhenhe Suo (79154), Jian Liu (33711), Trond Stokke (66426), Jahn M. Nesland (205661), Gunnar Kvalheim (7747), Karol Axcrona (336664)   +7 more
core   +1 more source

HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. [PDF]

, 2016
BackgroundDuring short-term hypoxia, Hypoxia Inducible Factors (particular their subunits HIF-1α and HIF-2α) regulate the expression of many genes including the potent angiogenesis stimulator VEGF. However, in some pathological conditions chronic hypoxia
Victor W M van Hinsbergh, Victor M. W. van Hinsbergh (3142851), Pieter Koolwijk (284312), Pieter Koolwijk, Ester M. Weijers (755095), Monique C. A. Duyndam (3142848), Tessa D. Nauta (3142845), Victor M W van Hinsbergh, Monique C A Duyndam, Ester M Weijers, Tessa D Nauta   +10 more
core   +1 more source

HIF-2α not HIF-1α overexpression confers poor prognosis in non–small cell lung cancer

Tumor Biology, 2017
HIF-α may play an important role in the process of tumorigenesis as well as tumor progression. Although a number of investigations have established the significance of HIF-1α in several human tumors, there is still little information available on the ...
Zhao-Jia Gao, Yong Wang, Wei-dong Yuan, Jun-qiang Yuan, Kai Yuan   +4 more
doaj   +1 more source

HIF-2α and HIF-2β immunohistochemical expression in the kidney.

, 2015
Kidney immunohistochemical expression of HIF-2α (A) and HIF-2β (B) in the renal cortex of sham (1) and CRF (2) rats and corresponding Quick scores (3). Results are presented as mean ± SEM: ***- p < 0.001 versus Sham group.
Helena Vala (721720), João Fernandes (573142), Flávio Reis (721721), Petronila Rocha-Pereira (573147), Elísio Costa (573143), Elsa Bronze-da-Rocha (573141), Sandra Ribeiro (721719), Luís Belo (573138), Patrícia Garrido (721718), Alice Santos-Silva (573149)   +9 more
core   +1 more source

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance [PDF]

, 2015
Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples ...
Gezer, Deniz, Tessa L. Holyoake, Ratcliffe, Peter, Ratcliffe, Peter J., Iglesias, Juan Manuel, O'Duibhir, Eoghan, Panagopoulou, Theano I., Villacreces, Arnaud, Amelie V. Guitart, Ratcliffe, Peter J, Holyoake, Tessa L., Holyoake, Tessa L, Glykofrydis, Fokion, So, Chi Wai Eric, Sepulveda, Catarina, Panagopoulou, Theano I, Milica Vukovic, Dónal O'Carroll, Kranc, Kamil R, Juan Menendez-Gonzalez, Lewis Allen, Juan Manuel Iglesias, Peter J. Ratcliffe, Arnaud Villacreces, Holyoake, Tessa, Schaak, Katrin, Alasdair Ivens, Kamil R. Kranc, Vukovic, Milica, Deniz Gezer, Armesilla-Diaz, Alejandro, Guitart, Amelie V., Ivens, Alasdair, Guitart, Amelie V, Chithra Subramani, Chi Wai Eric So, Fokion Glykofrydis, Alejandro Armesilla-Diaz, Katrin Schaak, Panagopoulou, Theano, Allen, Lewis, Kranc, Kamil R., Eoghan O'Duibhir, O'Carroll, Dónal, Post, Annemarie E M, Theano I. Panagopoulou, Post, Annemarie E.M., Wood, Andrew, Catarina Sepulveda, Annemarie E.M. Post, Andrew Wood, Subramani, Chithra, Guitart, Amelie, V, Kranc, Kamil, Menendez-Gonzalez, Juan   +54 more
core   +1 more source

Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.

PLoS Biology, 2014
Rheumatoid arthritis (RA) is a systemic autoimmune disorder that manifests as chronic inflammation and joint tissue destruction. However, the etiology and pathogenesis of RA have not been fully elucidated.
Je-Hwang Ryu, Chang-Suk Chae, Ji-Sun Kwak, Hwanhee Oh, Youngnim Shin, Yun Hyun Huh, Choong-Gu Lee, Yong-Wook Park, Churl-Hong Chun, Young-Myeong Kim, Sin-Hyeog Im, Jang-Soo Chun   +11 more
doaj   +1 more source