Results 11 to 20 of about 57,100 (255)

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes [PDF]

Molecular Cancer, 2010
Background Activating KRAS mutations are important for cancer initiation and progression; and have recently been shown to cause primary resistance to therapies targeting the epidermal growth factor receptor.
Dang Duyen T, Cruz-Correa Marcia R, Washburn Joseph G, Johnson Craig, Chun Sang Y, Dang Long H   +5 more
doaj   +2 more sources

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

PLoS ONE, 2015
Hypoxia is a state of decreased oxygen reaching the tissues of the body. During prenatal development, the fetus experiences localized occurrences of hypoxia that are essential for proper organogenesis and survival.
Yogesh Saini, Steven P Proper, Peter Dornbos, Krista K Greenwood, Anna K Kopec, Scott G Lynn, Elizabeth Grier, Lyle D Burgoon, Timothy R Zacharewski, Russell S Thomas, Jack R Harkema, John J LaPres   +11 more
doaj   +2 more sources

IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

Journal of Orthopaedic Translation
Background: Chondrocyte hypertrophy is a potential target for osteoarthritis (OA) treatment, with Indian hedgehog (IHH), glioma-associated oncogene homolog (GLI), and hypoxia-inducible factor-2α (HIF-2α) being closely associated with chondrocyte ...
Chengming Zhang, Ruipeng Zhao, Zhengquan Dong, Yang Liu, Mengrou Liu, Haoqian Li, Yukun Yin, Xianda Che, Gaige Wu, li Guo, Pengcui Li, Xiaochun Wei, Ziquan Yang   +12 more
doaj   +2 more sources

Upregulation of the Chemokine Receptor CCR7 expression by HIF-1αand HIF-2α in non-small cell lung cancer

Chinese Journal of Lung Cancer, 2008
Background and objective CCR7 is closely related with the lymph node metastasis of non-small cell lung cancer. The objective of this work is to investigate the expressions of chemokine receptor CCR7, hypoxiainducible factor 1α (HIF-1α) and hypoxia ...
Yang LI, Qingfu ZHANG, Lili JIANG, Xueshan QIU, Enhua WANG   +4 more
doaj   +1 more source

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species

, 2019
Inactivation of the VHL tumor suppressor gene is the signature initiating event in clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, and causes the accumulation of hypoxia-inducible factor 2α (HIF-2α).
WG Kaelin (21908981), Z Tariq (21908969), LA Stransky (21908975), S Signoretti (21908978), N Perrimon (2679), BE Housden (21873275), HE Nicholson (21908966), RB Jennings (21908972)   +7 more
core   +5 more sources

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. [PDF]

, 2011
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer. Up to 91% have biallelic inactivation of VHL, resulting in stabilisation of HIF-α subunits.
T Bhattacharyya, M A Esteban, S Kiriakidis, Kiriakidis, S, P H Maxwell, Barod, R, M N Khan, Connor, T, Andrikopoulos, P, Bhattacharyya, T, Ashcroft, M, R Barod, T Connor, M Ashcroft, Khan, MN, Maxwell, PH, Esteban, MA, P Andrikopoulos   +17 more
core   +2 more sources

Hypoxia inducible factors and hypoxia associated factor expression profiles and prognostic significance in renal cell carcinomas

Medicine Science, 2023
Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists
Merve Meryem Kiran, Nuran Sungu, Hayriye Tatli Dogan, Arslan Ardicoglu, Fazli Erdogan, Berrak Gumuskaya   +5 more
doaj   +1 more source

Effects of HIF-2α on Biological Function of Breast Cancer MCF-7 Cells

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the effect of HIF-2α on proliferation, invasion and colony forming abilities of breast cancer MCF-7 cells. Methods HIF-2α ORF/shRNA lentivirus vectors were transfected into MCF-7 cells respectively, and then we screened and ...
LIU Yuqiong, LI Na, HUANG Huifen, LI Huixiang   +3 more
doaj   +1 more source

Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.

PLoS ONE, 2013
Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress.
Jayasri Nanduri, Damodara Reddy Vaddi, Shakil A Khan, Ning Wang, Vladislav Makerenko, Nanduri R Prabhakar   +5 more
doaj   +1 more source

Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility [PDF]

Open Biology, 2016
Cellular adaptation to hypoxia occurs via a complex programme of gene expression mediated by the hypoxia-inducible factor (HIF). The oxygen labile alpha subunits, HIF-1α/-2α, form a heterodimeric transcription factor with HIF-1β and modulate gene ...
S. E. Taylor, J. Bagnall, D. Mason, R. Levy, D. G. Fernig, V. See   +5 more
doaj   +1 more source