Results 41 to 50 of about 57,100 (255)

High Degree of Parasitemia Induces Placental Hypoxia and Low Birth Weight

Journal of Agromedicine and Medical Sciences (AMS), 2022
Placental malaria causes low fetal weight associated with infiltration of monocytes and parasites in the placenta resulting in placental hypoxia. Hypoxia is characterized by HIF expression.
Nurfianti Indriana, Zainabur Rahmah, Alvi Milliana   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Clinical and Developmental Immunology, 2013
This study aimed to examine HIF-2α, TWIST, and CXCR4 expression in papillary thyroid carcinoma (PTC) and assesses the association of their expression with clinicopathological indicators. HIF-2α, TWIST, and CXCR4 protein expression in 129 PTCs, 61 nodular
Ni Wang, Hao-Jun Luo, Guo-Bing Yin, Chao-Ran Dong, Man Xu, George G. Chen, Zhi-Min Liu   +6 more
doaj   +1 more source

Supplental Movie 2:Fast imaging of a HeLa cell ectopically expressing EGFP-HIF-2α. from Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility

, 2016
Cellular adaptation to hypoxia occurs via a complex program of gene expression mediated by the hypoxia-inducible factor (HIF). The oxygen labile alpha subunits, HIF-1α/-2α, form a heterodimeric transcription factor with HIF-1β and modulate gene ...
J. Bagnall (3114435), D. Mason (3114423), R. Levy (3114426), V. SEE (3114429), S. E. Taylor (3114438), D. G. Fernig (3114432)   +5 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

AMPK activation stabilizes HIF-2α by disrupting VHL binding and promotes erythroid differentiation under anemic stress via the mTOR pathway

Frontiers in Physiology
ObjectiveAnemia affects over two billion people globally, and ESA resistance poses major clinical hurdles. HIF-2α governs erythropoiesis, yet how AMPK/mTOR energy sensors regulate HIF-2α in erythroid cells remains unclear.
Yun Cen, Yun Cen, Pingjing Cai, Jinjin Jiang, Lihua Huang, Yiwei Hua   +5 more
doaj   +1 more source

Supplemental Movie 1: Time-lapse imaging in hypoxia of a single HeLa cell ectopically expressing EGFP-HIF-2α. from Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility

, 2016
Cellular adaptation to hypoxia occurs via a complex program of gene expression mediated by the hypoxia-inducible factor (HIF). The oxygen labile alpha subunits, HIF-1α/-2α, form a heterodimeric transcription factor with HIF-1β and modulate gene ...
J. Bagnall (3114435), D. Mason (3114423), R. Levy (3114426), V. SEE (3114429), S. E. Taylor (3114438), D. G. Fernig (3114432)   +5 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition

Redox Biology, 2023
The acquisition of the cancer stem cell (CSC) properties is often mediated by the surrounding microenvironment, and tumor hypoxia is considered an important factor for CSC phenotype development.
Steffanus Pranoto Hallis, Seung Ki Kim, Jin-Hee Lee, Mi-Kyoung Kwak   +3 more
doaj   +1 more source

Supplemental movie 5: Half-nucleus bleaching of a cell expressing EGFP-HIF-2α from Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility

, 2016
Cellular adaptation to hypoxia occurs via a complex program of gene expression mediated by the hypoxia-inducible factor (HIF). The oxygen labile alpha subunits, HIF-1α/-2α, form a heterodimeric transcription factor with HIF-1β and modulate gene ...
J. Bagnall (3114435), D. Mason (3114423), R. Levy (3114426), V. SEE (3114429), S. E. Taylor (3114438), D. G. Fernig (3114432)   +5 more
core   +1 more source