Results 51 to 60 of about 57,100 (255)
Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali +4 more
wiley +1 more source
Expression of HIF-1α and HIF-2α during the life cycle of the mammary gland.
, 2016 HIF-1α is expressed in luminal epithelial cells of pubertal and virgin adult mice. HIF-2α shows distinct expression in dispersed lactating luminal epithelial cells. HIF-2α was expressed during post-lactational involution. During involution, CK14-positive
Sven Påhlman (23247) +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn +6 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Hypoxic tumor microenvironment and maintenance of stemness contribute to drug resistance in breast cancer. However, whether Hypoxia-inducible factor-2α (HIF-2α) in hypoxic tumor microenvironment mediates conversion to a stem cell phenotype and
Yuanyuan Yan +7 more
doaj +1 more source
HIF-1α and HIF-2α are differentially up-regulated in RA synovium.
, 2014 (A) Representative images of human RA synovium immunostained for HIF-1α, HIF-2α, IL6, MMP3, and MMP13 (n = 10). (B) Representative images of human RA and mouse CIA synovial sections (n = 8) immunostained for HIF-2α and a RA synovium marker (MMP3, MMP13 ...
Choong-Gu Lee (575970) +11 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang +4 more
wiley +1 more source
HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma
The Journal of Clinical InvestigationClear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2α signaling. Identifying means to regulate HIF-2α thus has potential therapeutic benefit.
Zachary A. Bacigalupa +12 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2018 This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions.
Peng-Li Luo +3 more
doaj +1 more source
Translational Oncology, 2020 Background: In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis.
Jessica Iorio +16 more
doaj +1 more source