Results 71 to 80 of about 57,100 (255)

HIF-1α and HIF-2α: synergistic regulation of glioblastoma malignant progression during hypoxia and apparent chemosensitization in response to hyperbaric oxygen

Cancer Cell International
Glioblastoma multiforme (GBM), the most malignant type of brain tumour, is regulated mainly by a hypoxic microenvironment. Previous studies have focused mainly on the effects of hypoxia inducible factor-1α (HIF-1α) or hypoxia inducible factor-2α (HIF-2α)
Pan Wang, Sheng Gong, Bin Liao, Jie Liu, Lu Zhao, Nan Wu   +5 more
doaj   +1 more source

Suppression of hepcidin transcript levels is not mediated by HIF-1α or HIF-2α.

, 2013
(A) SiRNA-mediated knock-down of HIF-1α (1α) or HIF-2α (2α) did not attenuate the down-regulation of hepcidin mRNA levels in HepG2 cells after 16 h of stimulation; luciferase (luc) siRNA served as negative control.
Bernd Klanke (186110), Christina Warnecke (369153), Anja-Katrin Bosserhoff (312341), Ulrike Maegdefrau (369152), Gunnar Schley (186149), Melanie Volke (369151), Daniel P. Gale (288230), Kai-Uwe Eckardt (186164), Patrick H. Maxwell (22308)   +8 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

MicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes

Scientific Reports, 2017
Endothelial Per-Arnt-Sim domain protein-1/hypoxia-inducible factor-2α (EPAS-1/ HIF-2α) is a catabolic transcription factor that regulates osteoarthritis (OA)-related cartilage destruction.
Hyun Sook Hwang, Su Jin Park, Mi Hyun Lee, Hyun Ah Kim   +3 more
doaj   +1 more source

Effects of HIF-1α and HIF-2α inhibition by si-RNA on PKM2 expression.

, 2018
PC3 and LNCaP cells were transfected and cultured for 24 h in normoxia 20% O2 or hypoxia 0.1% O2. (A) PKM2 mRNA expression detection and quantification by qRT-PCR after treatment of cells with si-HIF-1α or si-HIF-2α (n = 4, Mean ± SEM, *** P § P < 0.05 ...
Nafez Abu Tarboush (1911160), Oleg Pak (5748923), Diya Hasan (1874752), Elisabetta Gamen (5748920), Belal Azab (403805), Yazan Ismail (161231)   +5 more
core   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors.

PLoS ONE, 2013
CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood.
Shunsuke Ohnishi, Osamu Maehara, Koji Nakagawa, Ayano Kameya, Kanako Otaki, Hirotoshi Fujita, Ryosuke Higashi, Kikuko Takagi, Masahiro Asaka, Naoya Sakamoto, Masanobu Kobayashi, Hiroshi Takeda   +11 more
doaj   +1 more source

Hif-2α promotes degradation of Mammalian peroxisomes by selective autophagy

, 2014
Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate ...
Schönenberger, Miriam J, Moser, Ann B, Gerber, Philipp A, Lucas, Miriam S.; id_orcid, Köfeler, Harald C, Kovacs, Werner J, Walter, Katharina M., Horn, Michael, Trötzmüller, Martin, Elsässer, Hans-Peter, Faust, Phyllis L, Faust, Phyllis L., Walter, Katharina M, Krek, Wilhelm, Moch, Holger, Lucas, Miriam S, Schwarz, Tobias, Gerber PA, Kovacs WJ, Köfeler HC, Krek W, Trötzmüller M, Schwarz T, Faust PL, Moch H, Schönenberger MJ, Walter KM, Moser AB, Elsässer HP, Lucas MS, Horn M, Gerber, Philipp A., Köfeler, Harald C., Kovacs, Werner J., Moser, Ann B., Schönenberger, Miriam J.   +35 more
core   +1 more source

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways [PDF]

, 2013
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M, Carroll, VA, Selvarajah, J, Moumen, A, Nathawat, K   +4 more
core   +2 more sources

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source