Results 81 to 90 of about 57,100 (255)

Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α

Nature Communications
Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH is a growing global health concern due to its increasing morbidity, lack of well-defined biomarkers and lack of clinically effective treatments ...
Jialin Xia, Hong Chen, Xiaoxiao Wang, Weixuan Chen, Jun Lin, Feng Xu, Qixing Nie, Chuan Ye, Bitao Zhong, Min Zhao, Chuyu Yun, Guangyi Zeng, Yuejian Mao, Yongping Wen, Xuguang Zhang, Sen Yan, Xuemei Wang, Lulu Sun, Feng Liu, Chao Zhong, Pengyan Xia, Changtao Jiang, Huiying Rao, Yanli Pang   +23 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

HIF-1α and HIF-2α expression in mouse kidney.

, 2012
The physiological expression pattern of HIF-1α and HIF-2α was analyzed by immunohistochemistry on kidney sections of normoxic and hypoxic (6 h, 7% O2) mice.
Ruth E. Schietke (186088), Christian Rosenberger (186134), Bernd Klanke (186110), Christina L. Warnecke (186114), Thomas Winkler (127802), Karl X. Knaup (186120), Gunnar Schley (186149), Kai-Uwe Eckardt (186164), Thomas Hackenbeck (186093), Robert Koesters (186139), Peter Betz (186146), Maxine Tran (186098), Johannes Schödel (186151), Carsten Willam (186156), Michael S. Wiesener (186173), Deepa Shukla (186127), Regina Günther (186104), Sebastian Bachmann (186143), Patrick Maxwell (186169), Kerstin Amann (186160)   +19 more
core   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Expression and correlation of HIF-1α, HIF-2α and HAF in ccRCC.

, 2018
(A, C and E) Positive nuclear staining to HIF-1α, HIF-2α and HAF, respectively, in primary ccRCCs at high magnification (x100). (B, D and F) Heterogenous nuclear staining of HIF-1α, HIF-2α and HAF, respectively, in a tumor at low magnification (x20). (G,
Nathalie Rioux-Leclercq (249571), Maeva Dufies (149669), Bérengère Dadone (4888705), Gilles Pages (4888711), Fanny Burel-Vandenbos (424912), Matthieu Durand (4888714), Delphine Borchiellini (4888702), Jean Amiel (543782), Nathalie M. Mazure (138007), Damien Ambrosetti (478657), Jacques Pouyssegur (4888708)   +10 more
core   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells

Frontiers in Endocrinology
Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence and affects approximately one-third of adults, owing to high-fat dietary habits and a sedentary lifestyle.
Ranran Yan, Ranran Yan, Ranran Yan, Ranran Yan, Hao Cai, Xiaofeng Zhou, Guodan Bao, Guodan Bao, Guodan Bao, Guodan Bao, Zhenzhong Bai, Zhenzhong Bai, Zhenzhong Bai, Zhenzhong Bai, Ri-li Ge, Ri-li Ge, Ri-li Ge, Ri-li Ge   +17 more
doaj   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α.

PLoS ONE, 2013
Tumor-associated macrophages (TAMs) constitute a major component of the leukocyte infiltrate of most solid tumors, and they usually exhibit a proangiogenic phenotype which facilitates tumor growth in most circumstances.
Zhenqun Xu, Lan Zhao, Ling-Yan Zhu, Min He, Limin Zheng, Yan Wu   +5 more
doaj   +1 more source

Stress induces CBP/HIF-2α interactions in HCT116 cells.

, 2023
(A) Detection of endogenous HIF-1α or HIF-2α in HCT116 whole cell extracts by immunoblotting after the indicated period of hypoxia exposure or glucose deprivation. Alpha-tubulin levels for each immunoblot are also shown.
Shelby D. Melton (14709834), Rui Chen (95310), Min Xu (15203), Robert E. Hammer (7865852), Joseph A. Garcia (7865855), Sarah A. Comerford (3854917), Linda A. Feagins (14709837)   +6 more
core   +1 more source