Results 61 to 70 of about 57,100 (255)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Upregulation of HIF-2α expression in TAMs.

, 2013
(A) Adjacent sections of paraffin-embedded HCC tissue (n = 9) were stained with an anti-HIF-2α or anti-CD68 antibody. (B) HIF-2α expression in macrophages from frozen sections of HCC tissue (n = 6) was analyzed by confocal microscopy.
Lan Zhao (5713), Yan Wu (70890), Zhenqun Xu (475960), Ling-Yan Zhu (475961), Min He (44052), Limin Zheng (385489)   +5 more
core   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

HIF-2α is essential for carotid body development and function. [PDF]

, 2018
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB).
Cowburn, A, Andrew S. Cowburn, Randall S Johnson, Macías, David, Andrew S Cowburn, Johnson, RS, Cowburn, Andrew S., López Barneo, José, Ortega-Sáenz, Patricia, Cowburn, Andrew S, Patricia Ortega-Sáenz, José López-Barneo, Lopez-Barneo, J, López-Barneo, José, Ortega Sáenz, Patricia, Randall Johnson, Johnson, Randall S, Macias, D, Johnson, R,, David Macías, Ortega-Saenz, P, Torres Torrelo, Hortensia, Cowburn, AS, Hortensia Torres-Torrelo, Torres-Torrelo, Hortensia, Torres-Torrelo, H, Randall S. Johnson, S., Johnson R, Johnson, Randall S.   +28 more
core   +3 more sources

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Acetate induces ACSS2-dependent CBP/HIF-2α interactions.

, 2015
(A) Acetylation of ectopic HA-tagged wild-type HIF-2α after pulldown (PD) and detection by immunoblotting (IB) after (4 hr) incubation with vehicle (Veh), or the short chain fatty acids acetate (Ac), propionate (Pr), and butyrate (Bu) with ...
Rui Chen (95310), Jason S. Nagati (692763), Robert D. Gerard (106674), Min Xu (15203), Joseph A. Garcia (692766), Richard T. Hogg (692764), Alok Das (692765)   +6 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin

Molecular Oncology, 2019
Ovarian cancer stem cells (OCSCs) are sources of tumor chemoresistance and recurrence. A hypoxic microenvironment contributes to the chemoresistance of cancer stem cells (CSCs), but the underlying mechanism is not fully understood yet. Here, we show that
Miao He, Huizhe Wu, Qian Jiang, Yinuo Liu, Li Han, Yuanyuan Yan, Binbin Wei, Fangxiao Liu, Xiaolan Deng, Huiying Chen, Lin Zhao, Min Wang, Xin Wu, Weifan Yao, Haishan Zhao, Jianjun Chen, Minjie Wei   +16 more
doaj   +1 more source

Association Between Hypoxia-Inducible Factor-2α (HIF-2α) Expression and Colorectal Cancer and Its Prognostic Role: a Systematic Analysis

Cellular Physiology and Biochemistry, 2018
Background/Aims: Although some studies showed that HIF-2α expression was correlated with an unfavorable prognosis in colorectal cancer (CRC), the prognostic results remain conflicting in CRC.
Susu Han, Tao Huang, Wen Li, Shanshan Liu, Wei Yang, Qi Shi, Hongjia Li, Jianlin Ren, Fenggang Hou   +8 more
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source