Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System [PDF]
JBMR Plus, 2023 Hypoxia‐inducible factors (HIFs) are oxygen‐dependent heterodimeric transcription factors that mediate molecular responses to reductions in cellular oxygen (hypoxia).
Sarah V Mendoza +2 more
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Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis [PDF]
Cells, 2022 Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way.
Ana Karen Torres-Soria +14 more
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Mitral stenosis severity and the hypoxic response: potential role of hypoxia-inducible factor-2α - a cross-sectional study [PDF]
BMC Cardiovascular DisordersBackground Mitral stenosis (MS) causes chronic pressure overload and secondary pulmonary hypertension, which are associated with activation of hypoxia-inducible pathways.
Meltem Uyaner Kan +3 more
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Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells [PDF]
Frontiers in EndocrinologyNon-alcoholic fatty liver disease (NAFLD) has a high global prevalence and affects approximately one-third of adults, owing to high-fat dietary habits and a sedentary lifestyle.
Ranran Yan +17 more
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Prevalence and prognosis of hypoxia‐inducible factor‐2α (HIF‐2α) pathway gene mutations across advanced solid tumors [PDF]
Cancer MedicineIntroduction Hypoxia‐inducible factor‐2α (HIF‐2α) modulates the hypoxic response pathway in tumors; however, mutations in pathways (including SDHA, SDHB, SDHC, SDHD, FH, and VHL genes) that are suspected to activate HIF‐2α are poorly understood, with ...
Wenjun Zhong +7 more
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Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition
Redox Biology, 2023 The acquisition of the cancer stem cell (CSC) properties is often mediated by the surrounding microenvironment, and tumor hypoxia is considered an important factor for CSC phenotype development.
Steffanus Pranoto Hallis +3 more
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Medicine Science, 2023 Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists
Merve Meryem Kiran +5 more
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General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain. [PDF]
PLoS ONE, 2011 Erythropoietin (EPO), originally identified as a hematopoietic growth factor produced in the kidney and fetal liver, is also endogenously expressed in the central nervous system (CNS).
Tomoharu Tanaka +6 more
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Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
BMC Research Notes, 2018 Objective Earlier studies from our group using hypoxia-inducible factor 3α knockout mice showed impairments in lung remodeling and lung endothelial cells.
Firman Zulkifli Amin +2 more
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Indonesian Journal of Cancer, 2019 Background: HIF-2α is a transcription factor in hypoxic condition, and high expression levels of it correlate with the concepts of metastasis, therapy opposition and reduced quality of prognosis in various forms of cancerous growth. Due to the exceedingly infiltrative ability of brain glioma cells, gliomas cannot be completely deteriorated with ...
Bagus Ramasha Amangku +3 more
openaire +2 more sources