Results 31 to 40 of about 4,538,639 (248)

The effects of hypoxia-inducible factors-1α and -2α and erythroferrone on hepcidin in patients with chronic kidney disease stages 3–5 and renal anemia

European Journal of Inflammation, 2022
Objective This study aimed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and erythroferrone (ERFE) on hepcidin in patients with chronic kidney disease (CKD) stages 3–5 and renal anemia.
Jianghuai Hong, Jingjing Lai, Xiaoying Chen, Yan Yan, Yanyan Hong, Hailun Ke, Jing Zheng   +6 more
doaj   +1 more source

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease

Nature Communications, 2018
Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and
Daniel Tarade, Claire M. Robinson, Jeffrey E. Lee, Michael Ohh   +3 more
doaj   +1 more source

Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer.

, 2021
A new phase I clinical trial has demonstrated that belzutifan provides a route to sustained inhibition of hypoxia-inducible factor 2α in humans that is well tolerated and could be useful in the treatment of advanced clear cell kidney ...

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Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis

, 2017
Hypoxia-inducible factor (HIF) is a key transcriptional factor in the response to hypoxia. Although the effect of HIF activation in chronic kidney disease (CKD) has been widely evaluated, the results have been inconsistent until now.
Han, Seung Hyeok, Ryu, Dong-Ryeol, Youn-Hee Choi, Susan E. Quaggin, 김민석, Ki-Hwan Han, Eremina, Vera, Tae-Hyun Yoo, Kang, Duk-Hee, Seung-Jung Kim, Park, Kyoung Sook, Seung Hyeok Han, Han, Ki-Hwan, Kwon, Kihwan, 강덕희, Choi, Youn-Hee, Park, Jung Tak, 권기환, Minsuk Kim, Kim, Seung-Jung, Lim, Beom Jin, 김승정, 류동열, Beom Jin Lim, Kihwan Kwon, Kang, Shin-Wook, Duk-Hee Kang, Kim, Minsuk, Bo Young Nam, Jung Tak Park, Shina Lee, Kyu Bok Choi, Choi, Kyu Bok, Shin-Wook Kang, Nam, Bo Young, Yoo, Tae-Hyun, Vera Eremina, 최규복, Quaggin, Susan E., 한기환, Lee, Shina, Kyoung Sook Park, Dong-Ryeol Ryu, Hyung Jung Oh, Kong, Kyoung Hye, Kyoung Hye Kong, Oh, Hyung Jung, 최윤희   +47 more
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Current research on the HIF-2α-EPO–Hb axis in hypoxic environments: from molecular mechanisms to clinical

Frontiers in Medicine
Hypoxic environments modulate downstream gene expression via activation of the hypoxia-inducible factor (HIF) signaling pathway, which facilitates adaptive responses to low oxygen.
Qiaochu Zheng, Yinglan Li, Yinglan Li, Jimei Li, Jimei Li, Jimei Li   +5 more
doaj   +1 more source

Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.

PLoS ONE, 2013
Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress.
Jayasri Nanduri, Damodara Reddy Vaddi, Shakil A Khan, Ning Wang, Vladislav Makerenko, Nanduri R Prabhakar   +5 more
doaj   +1 more source

Supplementary Figure 1 from Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-I

, 2006
Supplementary Figure 1 from Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-
Anca Irinel Catrina (14980252), Sergiu-Bogdan Catrina (437365), Lorenz Poellinger (216343), Kerstin Brismar (135185), Pawan Pyakurel (79865), Octavian Savu (14980255), Magnus Axelson (227628), Peter Biberfeld (79867), Ileana Ruxandra Botusan (4955797), Anja Rantanen (14980249)   +9 more
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High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α

, 2021
High aldehyde dehydrogenase (ALDH) activity has been recognized as a marker of cancer stem cells (CSCs) in breast cancer. In this study, we examined whether inhibition of ALDH activity suppresses stem-like cell properties in a 4T1 syngeneic mouse model ...
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Temporal induction of intestinal epithelial hypoxia-inducible factor (HIF)-2α is sufficient to drive colitis.

, 2019
We used a new mouse model to evaluate the role of temporal induction of intestinal epithelial hypoxia-inducible factor (HIF)-2α in driving ...
Samantha N. Devenport (6867099), Yatrik M. Shah (445526), Sumeet Solanki (6867086), Sadeesh K. Ramakrishnan (6867101)   +3 more
core   +1 more source

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska, Yasinska Inna M., Sumbayev Vadim V., Oniku Abraham E., Gibbs Bernhard F.   +15 more
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