Results 31 to 40 of about 57,100 (255)

HIF-2α regulates proliferation, invasion, and metastasis of hepatocellular carcinoma cells via VEGF/Notch1 signaling axis after insufficient radiofrequency ablation

Frontiers in Oncology, 2022
Background and AimsAlthough insufficient radiofrequency ablation (RFA) promotes the recurrence and metastasis of liver cancer, the underlying mechanism remains unclear.
Yongguang Yang, Yongguang Yang, Weifeng Chen, Weiheng Mai, Yi Gao, Yi Gao   +5 more
doaj   +1 more source

HIF-2α deletion promotes Kras-driven lung tumor development [PDF]

, 2010
Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1α and HIF-2α are overexpressed in many human NSCLCs, and constitutive HIF-2α activity ...
Pant, Dhruv K., Durham, Amy C., Jolly Mazumdar, Chodosh, Lewis A., Jacks, Tyler E, Michele M. Hickey, Alejandro Sweet-Cordero, Keith, Brian, Mazumdar, Jolly, Hickey, Michele M., Dhruv K. Pant, Brian Keith, Tyler Jacks, Amy C. Durham, M. Celeste Simon, Joseph L. Kissil, Sweet-Cordero, Alejandro, Anil Vachani, Simon, M. Celeste, Lewis A. Chodosh, Vachani, Anil, Kissil, Joseph L.   +21 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hif-2α regulates lipid metabolism in alcoholic fatty liver disease through mitophagy

Cell & Bioscience, 2022
Background Disordered lipid metabolism plays an essential role in both the initiation and progression of alcoholic fatty liver disease (AFLD), and fatty acid β-oxidation is increasingly considered as a crucial factor for controlling lipid metabolism. Hif-
Mei-fei Wu, Guo-dong Zhang, Tong-tong Liu, Jun-hao Shen, Jie-ling Cheng, Jie Shen, Tian-yu Yang, Cheng Huang, Lei Zhang   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Age-Related Expression and Localization of HIF-1α and HIF-2α in Different Tissues of Yak

Oxygen
The yak (Bos grunniens), a unique bovine species that is endemic to the Qinghai–Tibet Plateau and adjacent mountainous regions, exhibits remarkable adaptations to chronic high-altitude hypoxia.
Qin Wu, Huan Yang, Junyu Chen, Zhixin Chai, Hongwen Zhao, Zhijuan Wu   +5 more
doaj   +1 more source

Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System

JBMR Plus, 2023
Hypoxia‐inducible factors (HIFs) are oxygen‐dependent heterodimeric transcription factors that mediate molecular responses to reductions in cellular oxygen (hypoxia).
Sarah V Mendoza, Damian C Genetos, Clare E Yellowley   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

HIF-2α downregulation in the absence of functional VHL is not sufficient for renal cell differentiation

Cancer Cell International, 2007
Background Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-α)
Burk Robert D, Alexander Ashlynn E, Kapllani Erilda, Hughes Michael D, Schoenfeld Alan R   +4 more
doaj   +1 more source