Results 61 to 70 of about 23,244 (239)

DOK1 facilitates the advancement of ccRCC

Journal of Cancer
Background: Renal cell carcinoma (RCC) is one of the most common human cancers. Clear cell renal cell carcinoma (ccRCC) is a major subtype of RCC. However, the molecular mechanisms underlying ccRCC oncogenesis require further investigation. Docking protein 1 (DOK1) is a putative tumor suppressor gene; however, its role in ccRCC remains unclear. Methods:
Xie, Wei, Zhang, Yuanfeng, Shu, Bian, Zhang, Zhechuan, Zhang, Ronggui   +4 more
openaire   +2 more sources

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC

Cell Metabolism, 2023
Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".
Cerise Tang, Amy X. Xie, Eric Minwei Liu, Fengshen Kuo, Minsoo Kim, Renzo G. DiNatale, Mahdi Golkaram, Ying-Bei Chen, Sounak Gupta, Robert J. Motzer, Paul Russo, Jonathan Coleman, Maria I. Carlo, Martin H. Voss, Ritesh R. Kotecha, Chung-Han Lee, Wesley Tansey, Nikolaus Schultz, A. Ari Hakimi, Ed Reznik   +19 more
openaire   +6 more sources

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Comparative analysis of genes with differential expression in the presence of PBRM1 between ccRCC cells and ccRCC TCGA biospecimen.

, 2016
(A) GO Biological Processes enriched by genes upregulated in TCGA ccRCC biospecimen with no PBRM1 mutation compared to ccRCC biospecimen with PBRM1 mutations.
Emily C. Dykhuizen (2400376), Matthew J. Schipma (2621923), Basudev Chowdhury (2182760), Christina R. Ferreira (461379), Elizabeth G. Porter (2041459), Jane C. Stewart (2621920)   +5 more
core   +1 more source

DataSheet_2_Cuproptosis in ccRCC: key player in therapeutic and prognostic targets.zip

, 2023
BackgroundClassical biomarkers have been used to classify clear cell renal cell carcinoma (ccRCC) patients in a variety of ways, and emerging evidences have indicated that cuproptosis is closely related to mitochondrial metabolism, thereby accelerating ...
Shaohua He (13202703), Chao Qin (119135), Zhongwen Lu (10134056), Qiang Li (8118), Hongqi Chen (425987), Yang Lv (279176), Lu Yin (183747)   +6 more
core   +1 more source

Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma

OncoImmunology, 2018
Sphingosine kinase 1 (SphK1) is the major source of the bioactive lipid and GPCR agonist sphingosine 1-phosphate (S1P). Although alterations in SphK1 expression and activity have been detected in various human malignancies, its potential molecular ...
Yunze Xu, Baijun Dong, Jianfeng Wang, Jin Zhang, Wei Xue, Yiran Huang   +5 more
doaj   +1 more source

Development of a candidate marker for ccRCC.

, 2016
(A) Expression values of CA9 correctly classified 30 of 32 samples in our FFPE dataset. (B) Whisker plot of expression value distribution in our FFPE dataset for CA9.
Christian Beisland (2268835), Vidar Beisvag (83084), Trude Skogstrand (838195), Hans-Peter Marti (271779), Sabine Leh (838196), Karin Hjelle (2268829), Arnar Flatberg (38409), Oystein Eikrem (2268832), Lea Landolt (2268838), Andreas Scherer (2268826)   +9 more
core   +1 more source

SAM between two ccRCC identified groups.

, 2020
SAM between two ccRCC identified groups.
Guillermo de Velasco (3457934), Enrique Espinosa (175501), Angelo Gámez-Pozo (175480), Andrea Zapater-Moros (6896114), Elena López-Camacho (8506821), Carlos A. Farfán Tello (8506818), Natalia Miranda (8506815), Lucía Trilla-Fuertes (4096813), Álvaro Pinto (6896129), Daniel Castellano (514160), Rocío López-Vacas (175488), Guillermo Prado-Vázquez (4096810), Juan Ángel Fresno Vara (8506824), Felipe Villacampa (3559574)   +13 more
core   +1 more source

DataSheet_1_Cuproptosis in ccRCC: key player in therapeutic and prognostic targets.zip

, 2023
BackgroundClassical biomarkers have been used to classify clear cell renal cell carcinoma (ccRCC) patients in a variety of ways, and emerging evidences have indicated that cuproptosis is closely related to mitochondrial metabolism, thereby accelerating ...
Shaohua He (13202703), Chao Qin (119135), Zhongwen Lu (10134056), Qiang Li (8118), Hongqi Chen (425987), Yang Lv (279176), Lu Yin (183747)   +6 more
core   +1 more source

Metabolic Reprogramming in Kidney Cancer: Implications for Therapy

Annals of Urologic Oncology
Kidney cancer, particularly clear cell renal cell carcinoma (ccRCC), has emerged as a paradigm for cancer metabolic reprogramming, exhibiting distinctive alterations that drive tumor progression and therapeutic resistance.
Elena Tena Edo
doaj   +1 more source