Results 51 to 60 of about 23,244 (239)

DataSheet_4_Cuproptosis in ccRCC: key player in therapeutic and prognostic targets.zip

, 2023
BackgroundClassical biomarkers have been used to classify clear cell renal cell carcinoma (ccRCC) patients in a variety of ways, and emerging evidences have indicated that cuproptosis is closely related to mitochondrial metabolism, thereby accelerating ...
Shaohua He (13202703), Chao Qin (119135), Zhongwen Lu (10134056), Qiang Li (8118), Hongqi Chen (425987), Yang Lv (279176), Lu Yin (183747)   +6 more
core   +1 more source

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC

Cell Death & Disease, 2023
AbstractClear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is associated with poor prognosis. The histone H3 lysine 36 methyltransferase SET-domain-containing 2 (SETD2) has been reported to be expressed at low levels and frequently mutated in ccRCC.
Wei Xue, Wengang Jian, Yuyang Meng, Tengda Wang, Licheng Cai, Yongchun Yu, Yipeng Yu, Zhinan Xia, Cheng Zhang   +8 more
openaire   +3 more sources

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Distribution of GRP78 expression in ccRCC associated perinephric adipose tissue (N = 60) among different categories of ccRCC aggressiveness.

, 2019
Distribution of GRP78 expression in ccRCC associated perinephric adipose tissue (N = 60) among different categories of ccRCC aggressiveness.
Sharon Juliet Del Vecchio (6239654), Robert J. Ellis (668685), David W. Johnson (221347), Glenda C. Gobe (3630025), David A. Vesey (3234039), Armando Teixeira-Pinto (101747), Michael A. McGuckin (128370), Yeoungjee Cho (6239657), Kunyu Shen (6239651)   +8 more
core   +1 more source

Single-Cell Sequencing to Identify Six Heat Shock Protein (HSP) Genes-Mediated Progression Subtypes of Clear Cell Renal Cell Carcinoma

International Journal of General Medicine, 2021
Qinke Li, Maoqing Lu, Zhechuan Zhang, Ronggui Zhang Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Ronggui ZhangDepartment of Urology, The Second Affiliated ...
Li Q, Lu M, Zhang Z, Zhang R
doaj  

High Hepcidin expression predicts poor prognosis in patients with clear cell renal cell carcinoma

Diagnostic Pathology, 2022
Clear cell renal cell carcinoma (ccRCC) is a growing public health challenge worldwide. Hepcidin antimicrobial peptide (HAMP) is differentially expressed in various tumors. However, the roles and functions of HAMP in ccRCC remain unclear.
Yuting Tang, Shengdong Ge, Xiao Zheng, Jiejiao Zheng   +3 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

FUBP1 is upregulated in ccRCC tissue and cell lines.

, 2017
(A) FUBP1 mRNA levels in ccRCC and matched normal renal tissues were analyzed by qRT-PCR. The expression levels of FUBP1 mRNA were normalized to that of PPIA, the internal control. (B) Correlation between FUBP1 mRNA levels and TNM stage of ccRCC.
Xintao Li (2212051), Qingshan Du (2226748), Hanfeng Wang (3633178), Yu Gao (69071), Shengpan Wu (3633184), Xin Ma (37268), Jianwen Chen (2211184), Dong Ni (172495), Yang Fan (220863), Xu Bao (3633187), Yu Zhang (12946), Xu Zhang (49484), Junyao Duan (3633181), Fan Zhang (46132)   +13 more
core   +1 more source

Prognostic Value of an m5C RNA Methylation Regulator-Related Signature for Clear Cell Renal Cell Carcinoma

Cancer Management and Research, 2021
Hanrong Li,1 Huiming Jiang,2 Zhicheng Huang,2 Zhilin Chen,2 Nanhui Chen2 1Department of Extracorporeal Shock Wave Lithotripsy, Meizhou People’s Hospital (Huangtang Hospital), Meizhou, Guangdong, People’s Republic of China; 2Department of Urology, Meizhou
Li H, Jiang H, Huang Z, Chen Z, Chen N
doaj  

ATAD2 promotes glycolysis and tumor progression in clear cell renal cell carcinoma by regulating the transcriptional activity of c-Myc

Discover Oncology, 2023
Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urogenital tract. Given that ccRCC is often resistant to radiotherapy and traditional chemotherapy, the clinical treatment of patients with ccRCC remains a challenge.
Zonglong Wu, Liyuan Ge, Yimeng Song, Shaohui Deng, Peichen Duan, Tan Du, Yaqian Wu, Zhanyi Zhang, Xiaofei Hou, Lulin Ma, Shudong Zhang   +10 more
doaj   +1 more source