Results 261 to 270 of about 7,424,540 (294)
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Clear Cell Renal Cell Carcinoma
Clinics in Laboratory Medicine, 2005Clear cell RCC is the most common type of RCC that occurs in adults. It has the worst prognosis among the common epithelial tumors of the kidney. Histologically, a wide range of morphologic patterns can be encountered. Those cases with a multi-locular cystic architecture are considered to be a distinct subtype because of the clinicopathologic features.
David J, Grignon, Mingxin, Che
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Misdiagnosis of clear cell renal cell carcinoma
Nature Reviews Urology, 2011Clear cell renal cell carcinoma (RCC) represents the most common histological subtype of malignant kidney tumors. Based on symptoms alone, clear cell RCC is indistinguishable from other histological classes of RCC unless the tumor is present in the context of an RCC syndrome. Histopathological examination is, therefore, important to accurately identify
Vladimir A, Valera, Maria J, Merino
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Biomarkers in clear cell renal cell carcinoma
Expert Review of Anticancer Therapy, 2007The treatment of advanced renal cell carcinoma (RCC) has evolved significantly following the identification of the von Hippel-Lindau (VHL) gene and the function of its protein, and subsequent development of antiangiogenic therapies. A series of clinical trials resulted in the approval of three new agents with significant activity in this disease ...
Saby, George, Ronald M, Bukowski
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Cell heterogeneity in clear cell renal cell carcinoma
APMIS, 2013The aim of this study was to define the histological spectrum, frequency and significance of nonconventional tumour cells in clear cell renal cell carcinomas (CCRCC). Fifty‐one totally sampled CCRCC were studied histologically to evaluate the spectrum of cell morphology variability, its frequency and significance, and their correlation with tumour ...
José I, Lopez +4 more
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An Immune Atlas of Clear Cell Renal Cell Carcinoma [PDF]
Cell, 2017 Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined.
Vito Riccardo Tomaso Zanotelli +2 more
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Therapeutic approaches in clear cell and non-clear cell renal cell carcinoma
Acta Clinica Belgica, 2016Renal cell carcinoma (RCC) accounts for 2.4% of all malignancies worldwide diagnosed with 338,000 estimated new cases globally in 2012. In the last decade, the therapeutic landscape for RCC patients has changed tremendously. In this review, we will summarize the treatment options currently available for clear-cell localized, advanced and metastatic RCC
T, Vermassen +3 more
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American Journal of Surgical Pathology, 2015
Clear cell papillary renal cell carcinoma is increasingly recognized as a distinct tumor with unique morphology, immunohistochemistry, and cytogenetics. Histopathology often mimics clear cell renal cell carcinoma; however, metastasis has not been reported, emphasizing the clinical value of recognizing these likely nonaggressive tumors.
Sean R, Williamson +8 more
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Clear cell papillary renal cell carcinoma is increasingly recognized as a distinct tumor with unique morphology, immunohistochemistry, and cytogenetics. Histopathology often mimics clear cell renal cell carcinoma; however, metastasis has not been reported, emphasizing the clinical value of recognizing these likely nonaggressive tumors.
Sean R, Williamson +8 more
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T2 CLEAR CELL RENAL CELL CARCINOMA IS A RARE ENTITY: A STUDY OF 120 CLEAR CELL RENAL CELL CARCINOMAS
Journal of Urology, 2005In 2002 the American Joint Committee on Cancer revised the TNM staging system, introducing subclassification for T1 tumors, and invasion of renal sinus fat and sinus veins in categories T3a and T3b, respectively. Since renal sinus invasion represents the most common site of extrarenal extension, the relationship between size, and renal sinus invasion ...
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Cytomorphology of clear cell papillary renal cell carcinoma
Cancer Cytopathology, 2016BACKGROUNDClear cell papillary renal cell carcinoma (CCPRCC) shares some morphologic and immunohistochemical markers with clear cell RCC and papillary RCC. To the author's knowledge, its cytomorphology on fine‐needle aspiration (FNA) or touch preparations (TPs) of core needle biopsy specimens has not been well delineated in the English language ...
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