Results 41 to 50 of about 1,965,245 (185)

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Changes in maximal clear corneal incision thickness (µm)and central corneal thickness (µm) for Intervention and Control groups at 1,7 and 30 Days.

, 2014
†Treatment effect defined as the change in the intervention group-the change in the control group.CCIT = clear corneal incision thickness.CCT =  central corneal thickness.Changes in maximal CCIT = postoperative maximal CCIT - preoperative CCIT.Changes in
Weirong Chen (406541), Jingjing Chen (293564), Xinyu Zhang (14029), Yizhi Liu (90863), Lixia Luo (406540), Bo Qu (150402), Zhuoling Lin (406545), Haotian Lin (82598)   +7 more
core   +1 more source

Femtosecond laser versus manual clear corneal incision in cataract surgery

, 2014
PURPOSE: To compare functional and morphological outcomes of femtosecond laser clear corneal incision (CCI) versus manual CCI during cataract surgery.
Mastropasqua R, Toto L, Vecchiarino L, Mastropasqua L, Di Nicola M, Pedrotti E, Mastropasqua A, Lisa Toto, MASTROPASQUA, ALESSANDRA, DI NICOLA, MARTA, Emilio Pedrotti, Alessandra Mastropasqua, Marta Di Nicola, Rodolfo Mastropasqua, TOTO, LISA, MASTROPASQUA, Leonardo, Leonardo Mastropasqua, Luca Vecchiarino, VECCHIARINO, LUCA   +18 more
core   +2 more sources

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Comparisons of the change in parameters between the corneal incision and sclera-corneal incision groups.

, 2017
Comparisons of the change in parameters between the corneal incision and sclera-corneal incision groups.
Yoshiaki Kiuchi (80320), Kanae Matsuya (3768943), Yoshitake Kato (294171), Shunsuke Nakakura (556508), Yuki Fujio (2124424), Ryo Asaoka (387326)   +5 more
core   +1 more source

The influence of corneal wound size on surgically induced corneal astigmatism after phacoemulsification

Journal of the Formosan Medical Association, 2012
To determine whether there is a difference in surgically induced astigmatism (SIA) after phacoemulsification for unsutured temporal clear corneal incisions of 2.5 mm and 3.5 mm wound sizes.
Yi-Hsuan Wei, Wei-Li Chen, Pei-Yuang Su, Elizabeth P. Shen, Fung-Rong Hu   +4 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Phacoemulsification Incision-Creation, Evaluation and Closure: A Review

Delhi Journal of Ophthalmology, 2019
Creating an ideal incision is the foremost and the most crucial step in phacoemulsification. The most commonly used incision for phacoemulsification is sutureless clear corneal incision (CCI).
Ajay Kumar Singh
doaj   +1 more source