Results 51 to 60 of about 23,245 (259)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Thermal Mismatch Effect and High-Temperature Tensile Performance Simulation of Hybrid CMC and Superalloy Bolted Joint by Progressive Damage Analysis

International Journal of Aerospace Engineering, 2020
The hybrid CMC and superalloy bolted joints have exhibited great potential to be used as thermostructural components of reusable space transportation systems, given the respective strengths of these two materials. In the high temperature excursion of the
Shuyuan Zhao, Jianglong Dong, Chao Lv, Zhengyu Li, Xinyang Sun, Wenjiao Zhang   +5 more
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A numerical coupling model for a multibody system with multiple lubricated clearance joints

MATEC Web of Conferences, 2017
In machines and mechanisms, most of the clearance joints are designed to operate with lubricant fluid, which is an effective way of ensuring better performance of the mechanical systems. The differently located lubricated joints interact with each other,
Bo Zhao, Fei Shen
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Research of the Dynamic Characteristic of Space Symmetrical Development Mechanism with Clearance Joint

Jixie chuandong, 2019
In order to study the influence of clearance joints on dynamic characteristics of space symmetrical deployment mechanism, based on an improved nonlinear impact force model, an space symmetrical deployment mechanism is used as an example, and comparative ...
Xupeng Wang, Geng Liu, Shangjun Ma, Ruiting Tong   +3 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Friction in Cylindrical Joints

Lubricants
Cylindrical clearance joints are commonly employed in mechanisms that involve the rotation of a shaft spindle within a cylindrical sliding bearing.
Andrei Marius Mihalache, Vasile Merticaru, Vasile Ermolai, Oana Dodun, Gheorghe Nagiț, Adelina Hrițuc, Marius Ionuț Rîpanu, Laurențiu Slătineanu   +7 more
doaj   +1 more source