Results 61 to 70 of about 73,235 (301)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Motion Accuracy and Dynamic Responses of Dual-Manipulator on Spacecraft Considering Clearance Joints

Aerospace
Clearance in joints caused by assemblage, manufacturing errors, and wear is inevitable, which will affect the dynamic performance of the dual-manipulator system on spacecraft.
Yiling Kuang, Zhengfeng Bai, Cheng Wei
doaj   +1 more source

Three-dimensional study for the relative positioning of mechanical elements in mechanisms constituted by parrallel joints with clearances [PDF]

, 2014
The great evolution of the data-processing tools during the last years allowed for the development of the computer aided design in the field of mechanical structures.
DAL SANTO, Philippe, POTIRON, Alain, YOUNES, Mohamad   +2 more
core   +2 more sources

Design and Evaluation of the LOPES Exoskeleton Robot for Interactive Gait Rehabilitation [PDF]

, 2007
This paper introduces a newly developed gait rehabilitation device. The device, called LOPES, combines a freely translatable and 2-D-actuated pelvis segment with a leg exoskeleton containing three actuated rotational joints: two at the hip and one at the
Asseldonk, Edwin H.F. van, Ekkelenkamp, Ralf, Hekman, Edsko E.G., Kooij, Herman van der, Kruidhof, Rik, Veneman, Jan F.   +5 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comparative Study on Calculation Method of Contact Force in Joint with Clearance of Crank Slider Mechanism

Jixie chuandong, 2021
In order to select the best contact force calculation method for the dynamics performance analysis of multibody systems involving joints with clearance， a dynamics model of a crank slider mechanism involving joints with clearance is established and a ...
Tingting Li, Zhenshan Zhang, Guohua Cui, Lianzhe Guan   +3 more
doaj  

Soldering device Patent [PDF]

, 1971
Soldering device particularly suited to making high quality wiring joints for aerospace engineering utilizing capillary attraction to regulate flow of ...
Booth, F. W.
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Shoulder and hip joint for hard space suits [PDF]

, 1986
Shoulder and hip joints for hard space suits are disclosed which are comprised of three serially connected truncated spherical sections, the ends of which converge. Ball bearings between the sections permit relative rotation.
Vykukal, H. C.
core   +1 more source