Results 61 to 70 of about 36,426 (210)

MACS-W: A modified optical clearing agent for imaging 3D cell cultures

Journal of Innovative Optical Health Sciences
Three-dimensional (3D) cell cultures have contributed to a variety of biological research fields by filling the gap between monolayers and animal models.
Xiang Zhong, Chao Gao, Hui Li, Yuening He, Peng Fei, Zaozao Chen, Zhongze Gu, Dan Zhu, Tingting Yu   +8 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Melanin Zinc Complex as a Biocompatible Agent for Clearing Bacteremia

Advanced Materials Interfaces
Sepsis, whole‐body inflammation caused by the contamination of blood by bacteria and endotoxins, affects millions of patients annually with high mortality rates.
Tahmineh Rahmani Eliato, Seth Edwards, Zhen Tian, Cheryl P. Andam, Kyung Jae Jeong, Young Jo Kim   +5 more
doaj   +1 more source

Clearing in financial networks with constrained equal awards

Informatika
Objectives. Financial networks with a rule of constrained equal awards for the distribution of the agent’s estate between its creditors are considered. The aim of the study is to develop an algorithm for constructing greatest clearing matrices for such ...
Ya. M. Shafransky
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Honey and olive oil as bio-friendly substitutes for formalin and xylene in routine histopathology

Indian Journal of Dental Research, 2017
Background: Formalin has long been the standard fixative and xylene has been the clearing agent for routine histopathology and immunohistochemistry worldwide.
Keerthi Muddana, Jaya Nagendra Krishna Muppala, Shyam Prasad Reddy Dorankula, Aruna Kumari Maloth, Pavan G Kulkarni, Deepsagar Thadudari   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On modeling random data to evaluate the performance of statistical tests in cryptography

Informatika
Objectives. Financial networks with a rule of constrained equal awards for the distribution of the agent’s estate between its creditors are considered. The aim of the study is to develop an algorithm for constructing greatest clearing matrices for such ...
U. Y. Palukha, M. A. Prokharchyk, Yu. S. Kharin   +2 more
doaj   +1 more source

Double Layer Dynamic Game Bidding Mechanism Based on Multi-Agent Technology for Virtual Power Plant and Internal Distributed Energy Resource

Energies, 2018
As renewable energies become the main direction of global energy development in the future, Virtual Power Plant (VPP) becomes a regional multi-energy aggregation model for large-scale integration of distributed generation into the power grid.
Yajing Gao, Xiaojie Zhou, Jiafeng Ren, Xiuna Wang, Dongwei Li   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source