Results 41 to 50 of about 36,426 (210)

Research on Bidding Strategy of Thermal Power Companies in Electricity Market Based on Multi-Agent Deep Deterministic Policy Gradient

IEEE Access, 2021
With the continuous improvement of new energy penetration in the power system, the price of the spot market of power frequently fluctuates greatly, which damages the income of a large number of thermal power enterprises.
Dunnan Liu, Yuan Gao, Weiye Wang, Zhixin Dong   +3 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice

Frontiers in Pharmacology, 2014
Although an increasing number of antibody conjugates are being used in the clinic, there remain many unmet needs in antibody targeting. Normal tissue background is one of the key issues that limits the therapeutic efficacy and detection sensitivity ...
Shuping eDou, John eVirostko, Mary eRusckowski, Dale eGreiner, Alvin ePowers, Guozheng eLiu   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bidding Strategy for Thermal Power Generation Companies Based on Multi-agent Deep Deterministic Policy Gradient Algorithm

Zhongguo dianli
Thermal power is an important support for the new power system. It is of great significance to study the bidding strategy for thermal power generation companies and the influence of different clearing mechanisms to ensure their low-carbon and efficient ...
Xingping ZHANG, Teng WANG, Xinyue ZHANG, Haonan ZHANG   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

OCT study of skin optical clearing with preliminary laser ablation of epidermis

Journal of Biomedical Photonics & Engineering, 2017
We report the results of the experimental study of optical immersion clearing of laboratory animals skin in vivo with preliminary laser ablation of epidermis.
Natalia S. Ksenofontova, Elina A. Genina, Alexey N. Bashkatov, Georgy S. Terentyuk, Valery V. Tuchin   +4 more
doaj   +1 more source

Optical histology: a method to visualize microvasculature in thick tissue sections of mouse brain. [PDF]

PLoS ONE, 2013
The microvasculature is the network of blood vessels involved in delivering nutrients and gases necessary for tissue survival. Study of the microvasculature often involves immunohistological methods.
Austin J Moy, Matthew P Wiersma, Bernard Choi   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source