Results 91 to 100 of about 15,002 (190)
The Rift Valley Fever virus protein NSm and putative cellular protein interactions
Virology Journal, 2012 Rift Valley Fever is an infectious viral disease and an emerging problem in many countries of Africa and on the Arabian Peninsula. The causative virus is predominantly transmitted by mosquitoes and high mortality and abortion rates characterize outbreaks
Engdahl Cecilia +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 2, January 2026.5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm +3 more
wiley +1 more source
, 2017 Mit nur wenigen Ausnahmen werden alle messengerRNAs (mRNAs) kotranskriptional modifiziert. Eine dieser Modifikationen stellt die Spaltung und Polyadenylierung am 3‘-Ende der Prä-mRNAs dar. Der gebildete Poly(A)-Schwanz bestimmt durch Auswirkungen auf die Stabilität sowie die Effizienz von mRNA-Export und Translation maßgeblich das Schicksal einer jeder
openaire +2 more sources
HemaSphere, Volume 10, Issue 1, January 2026.Abstract Diamond–Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosomal proteins, including RPS19, a component of the 40S ribosomal subunit.
Juraj Kokavec +13 more
wiley +1 more source
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
Translational control in plants: from basic mechanisms to environmental and developmental responses
The Plant Journal, Volume 125, Issue 1, January 2026.SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons +3 more
wiley +1 more source
PLoS ONE, 2012 The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse.
Nicole E Forbes +7 more
doaj +1 more source
Frontiers in Plant Science, 2016 Sugar beet (Beta vulgaris ssp. vulgaris) is a biennial, sucrose-storing plant, which is mainly cultivated as a spring crop and harvested in the vegetative stage before winter.
Conny Tränkner +11 more
doaj +1 more source
The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection.
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
doaj +1 more source
PLoS ONE, 2011 Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA)
Jihui Ping +19 more
doaj +1 more source