Results 91 to 100 of about 22,447 (214)

Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. [PDF]

, 1994
Andreas Jenny, H P Hauri, Walter Keller
openalex   +2 more sources

Genome-wide analysis of PAPS1-dependent polyadenylation identifies novel roles for functionally specialized poly(A) polymerases in Arabidopsis thaliana [PDF]

, 2015
The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression.
Becker, Jörg D., Bispo, Cláudia, Czesnick, Hjördis, de Moor, Cornelia, Kappel, Christian, Kolbe, Benjamin, Lenhard, Michael, Ramming, Anna, Trost, Gerda, Vi, Son Lang   +9 more
core   +4 more sources

Splicing to keep splicing: A feedback system for cellular homeostasis and state transition

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
ABSTRACT Background Alternative splicing (AS) plays a crucial role in regulating gene expression and governing proteomic diversity by generating multiple protein isoforms from a single gene. Increasing evidence has highlighted the regulation for pre‐mRNA splicing of the splicing factors (SFs).
Zhonghao Guo, Xurui Zhang, Yachen Li, Yule Chen, Yungang Xu   +4 more
wiley   +1 more source

Translational Control of Cyclin B1 mRNA during Meiotic Maturation: Coordinated Repression and Cytoplasmic Polyadenylation [PDF]

, 2000
Translational control is prominent during meiotic maturation and early development. In this report, we investigate a mode of translational repression in Xenopus laevis oocytes, focusing on the mRNA encoding cyclin B1.
Barkoff, Aaron F., Dickson, Kirsten S., Gray, Nicola K., Wickens, Marvin   +3 more
core   +1 more source

Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Adeno‐associated virus (AAV) is a non‐enveloped DNA virus infecting a wide variety of species, tissues, and cell types, which is recognized as a safe and effective method for delivering therapeutic transgenes. AAV vector is the most popular viral gene delivery system in clinical delivery systems with unique and multiple advantages, such as ...
Ling Yin, Hongliang He, Hongliang Zhang, Yuhua Shang, Chengbo Fu, Songquan Wu, Tengchuan Jin   +6 more
wiley   +1 more source

Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells [PDF]

, 2009
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene. Helping to explain this phenomenon,
Amrani, Bartel, Bishop, Calin, Chen, Christine Mayr, Coleman, Colgan, David P. Bartel, Derynck, Doyle, Edwalds-Gilbert, Evron, Fedele, Filipowicz, Flavell, Grimson, Grimson, Hauser, He, He, Hoeflich, Ji, Johnson, Kornblihtt, Lebwohl, Lee, Lee, Lewis, Lukas, Lutz, Majoros, Martincic, Mayr, Miyamoto, Moore, Nielsen, Noubissi, Ota, Primrose, Proudfoot, Rosenwald, Ross, Rowley, Ruther, Sandberg, Takagaki, Tessier, Tian, Veraldi, Vlasova, Wang, Wiestner, Wightman, Yu   +54 more
core   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization [PDF]

, 1987
Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasminogen activator (t-PA) and u-PA have been designed to direct the synthesis of new plasminogen activators and to investigate the structure-function ...
Andre, B., Bollen, A., Collen, D., Cravador, A., Deforesta, F., Dewilde, M., Gheysen, D., Herzog, A., Hoylaerts, M., Jacobs, P., Pierard, L., Topisirovic, L.   +11 more
core   +1 more source

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]

, 2018
Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P., Begolo, Daniela, Bengaly, Zakaria, Clayton, Christine, Freund, Yvonne, Gillingwater, Kirsten, Giordani, Federica, Pöhner, Ina, Rowan, Timothy G., Vincent, Isabel M., Wade, Rebecca C., Witty, Michael J.   +11 more
core   +3 more sources

Coevolution combined with molecular dynamics simulations provides structural and mechanistic insights into the interactions between the integrator complex subunits

Computational and Structural Biotechnology Journal, 2023
Finding the 3D structure of large, multi-subunit complexes is difficult, despite recent advances in cryo-EM technology, due to remaining challenges to expressing and purifying subunits.
Bernard Fongang, Yannick N. Wadop, Yingjie Zhu, Eric J. Wagner, Andrzej Kudlicki, Maga Rowicka   +5 more
doaj