Results 101 to 110 of about 15,002 (190)

A nucleoporin-associated signaling cascade controls plant immunity via histone modification

Genome Biology
Background Plants undergo massive transcriptional reprogramming upon pathogen infection. The transcription factors SAR DEFICIENT1 (SARD1) and CAM-BINDING PROTEIN 60-LIKE G (CBP60g) are master regulators of this process.
Leiwen Pan, Shun Peng, Yuehui Zhang, Huan Chang, Yi Yang, Dongbei Guo, Yuan Guo, Yakun Han, Ting Mao, Yuchen Huang, Shui Wang   +10 more
doaj   +1 more source

A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs

Journal of Nanobiotechnology
Methods Single-cell transcriptomics and high-throughput transcriptomics were used to screen factors significantly correlated with intervertebral disc degeneration (IDD). Expression changes of CFIm25 were determined via RT-qPCR and Western blot.
Xiao-Jun Yu, Yuan-Ting Zhao, Haimiti Abudouaini, Peng Zou, Tian-Qi Li, Xiao-Fan Bai, Shan-Xi Wang, Jian-Bin Guan, Meng-wei Li, Xiao-dong Wang, Ying-guang Wang, Ding-Jun Hao   +11 more
doaj   +1 more source

Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity.

PLoS Pathogens
Protein ubiquitination is essential for cellular homeostasis and regulation of several processes, including cell division and genome integrity. Ubiquitin E3 ligases determine substrate specificity for ubiquitination, and Cullin-RING E3 ubiquitin ligases (
Zeba Rizvi, G Srinivas Reddy, Somesh M Gorde, Priyanka Pundir, Divya Das, Puran Singh Sijwali   +5 more
doaj   +1 more source

CPSF4-mediated regulation of alternative splicing of HMG20B facilitates the progression of triple-negative breast cancer

Journal of Translational Medicine
Background Aberrant alternative splicing (AS) contributes to tumor progression. A crucial component of AS is cleavage and polyadenylation specificity factor 4 (CPSF4).
Guansheng Zhong, Qinyan Shen, Xinli Zheng, Kun Yu, Hongjiang Lu, Bajin Wei, Haidong Cui, Zhijun Dai, Weiyang Lou   +8 more
doaj   +1 more source

HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution. [PDF]

mBio
Luchsinger C, Dai AZ, Yalamanchili H, Balakrishnan A, Huang K-L, Bertelli C, Cui B, Lorenzo-Redondo R, Wagner EJ, Diaz-Griffero F.   +9 more
europepmc   +1 more source

PolyA-GLM: A comprehensive framework for <i>De novo</i> polyadenylation site prediction using genome language models. [PDF]

Comput Struct Biotechnol J
Saha S, Fahmi NA, Yong J, Zhang W.
europepmc   +1 more source

Poly(A) tail regulation in stem cells and early development. [PDF]

Cell Regen
Miao X, Hu G.
europepmc   +1 more source

The Role of mRNA Alternative Processing in Mammalian Neurodevelopment. [PDF]

Int J Mol Sci
Liu X, Zuo J, Zhang G, Han X, Tian Y.
europepmc   +1 more source

Molecular basis for the recognition of low-frequency polyadenylation signals by mPSF. [PDF]

Nucleic Acids Res
Huang L, Chu HF, Tong L.
europepmc   +1 more source

End of the line: a kinetic ruler model for poly(A) tail termination. [PDF]

Genes Dev
Corbett AH.
europepmc   +1 more source