Results 101 to 110 of about 22,447 (214)

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

PLoS ONE, 2012
The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse.
Nicole E Forbes, Jihui Ping, Samar K Dankar, Jian-Jun Jia, Mohammed Selman, Liya Keleta, Yan Zhou, Earl G Brown   +7 more
doaj   +1 more source

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. [PDF]

, 2009
BACKGROUND: Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for translation remains unclear.
Holt, Christine E, Huang, Yi-Shuian, Lin, Andrew C, Lin, Chien-Ling, Richter, Joel D, Strochlic, Laure, Tan, Chin Lik   +6 more
core   +4 more sources

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity [PDF]

, 2018
Termination is a ubiquitous phase in every transcription cycle but is incompletely understood and a subject of debate. We used gene editing as a new approach to address its mechanism through engineered conditional depletion of the 5′ → 3′ exonuclease ...
Bauer, David, Davidson, L, Eaton, JD, Kanemaki, MT, Natsume, T, West, S   +5 more
core   +2 more sources

A detailed analysis of the BR1 locus suggests a new mechanism for bolting after winter in sugar beet (Beta vulgaris L.)

Frontiers in Plant Science, 2016
Sugar beet (Beta vulgaris ssp. vulgaris) is a biennial, sucrose-storing plant, which is mainly cultivated as a spring crop and harvested in the vegetative stage before winter.
Conny Tränkner, Conny Tränkner, Ioana Maria Lemnian, Nazgol Emrani, Nina Pfeiffer, Surya Prasad Tiwari, Friedrich Kopisch-Obuch, Sebastian Vogt, Andreas E. Müller, Markus Schilhabel, Ivo Grosse, Christian Jung   +11 more
doaj   +1 more source

Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting [PDF]

, 2014
MicroRNA (miRNA) regulation clearly impacts animal development, but the extent to which development—with its resulting diversity of cellular contexts—impacts miRNA regulation is unclear.
Abreu-Goodger, Cei, Agarwal, Vikram, Bartel, David, Jan, Calvin H., Jan, Calvin H., Koppstein, David Neal Pira, Nam, Jin-Wu, Rissland, Olivia S., Rissland, Olivia S., Rodriguez, Antony, Yildirim, Muhammed A., Yildirim, Muhammed A.   +11 more
core   +1 more source

Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.

PLoS ONE, 2011
Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA)
Jihui Ping, Liya Keleta, Nicole E Forbes, Samar Dankar, William Stecho, Shaun Tyler, Yan Zhou, Lorne Babiuk, Hana Weingartl, Rebecca A Halpin, Alex Boyne, Jayati Bera, Jessicah Hostetler, Nadia B Fedorova, Katie Proudfoot, Dan A Katzel, Tim B Stockwell, Elodie Ghedin, David J Spiro, Earl G Brown   +19 more
doaj   +1 more source

Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision [PDF]

, 2012
Splicing of human pre-mRNA is reciprocally coupled to 3′ end formation by terminal exon definition, which occurs co-transcriptionally. It is required for the final maturation of most human pre-mRNAs and is therefore important to understand.
Davidson, L., West, S.
core   +3 more sources

Identification of Amino Acid Residues Responsible for Inhibition of Host Gene Expression by Influenza A H9N2 NS1 Targeting of CPSF30

Frontiers in Microbiology, 2018
H9N2 influenza A viruses (IAV) are considered low pathogenic avian influenza viruses (LPAIV). These viruses are endemic in poultry in many countries in Asia, the Middle East and parts of Africa.
Laura Rodriguez, Laura Rodriguez, Aitor Nogales, Munir Iqbal, Daniel R. Perez, Luis Martinez-Sobrido   +5 more
doaj   +1 more source

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection.

PLoS Pathogens
The early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K Singh, Gregory J Bedwell, Alan N Engelman, Adarsh Dharan, Edward M Campbell   +6 more
doaj   +1 more source

Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii [PDF]

, 2010
Yuya Nishida, H. Ishikawa, Seiki Baba, Noriko Nakagawa, Seiki Kuramitsu, Ryoji Masui   +5 more
openalex   +1 more source