RNA Structure Is a Critical Determinant of Poly(A) Site Recognition by Cleavage and Polyadenylation Specificity Factor [PDF]
Molecular and Cellular Biology, 1996 Sequence conservation among mammalian poly(A) sites is limited to the sequence AAUAAA, coupled with an amorphous downstream U- or GU-rich region. Since these sequences may also occur within the coding region of mRNAs, additional information must be required to define authentic poly(A) sites.
Brenton R. Graveley +2 more
semanticscholar +4 more sources
Human Immunodeficiency Virus Type 1 Tat Increases the Expression of Cleavage and Polyadenylation Specificity Factor 73-Kilodalton Subunit Modulating Cellular and Viral Expression [PDF]
Journal of Virology, 2004 ABSTRACTThe human immunodeficiency virus type 1 (HIV-1) Tat protein, which is essential for HIV gene expression and viral replication, is known to mediate pleiotropic effects on various cell functions. For instance, Tat protein is able to regulate the rate of transcription of host cellular genes and to interact with the signaling machinery, leading to ...
Marco A. Calzado +2 more
semanticscholar +4 more sources
A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor [PDF]
The EMBO Journal, 1997 Polyadenylation is the second step in 3' end formation of most eukaryotic mRNAs. In Saccharomyces cerevisiae, this step requires three trans-acting factors: poly(A) polymerase (Pap1p), cleavage factor I (CF I) and polyadenylation factor I (PF I). Here, we describe the purification and subunit composition of a multiprotein complex containing Pap1p and ...
Pascal Preker
semanticscholar +5 more sources
Comprehensive assessment of cleavage and polyadenylation specificity factors in hepatocellular carcinoma: Expression, prognostic significance and immune infiltration analysis. [PDF]
Mol Clin OncolHepatocellular carcinoma (HCC), a prevalent and highly malignant form of liver cancer, poses significant global health challenges. Previous studies have suggested that alterations in cleavage and polyadenylation specificity factors (CPSFs) play a role in the development and prognosis of HCC.
Lu Y, Wang T, Yan X, Zhang H.
europepmc +5 more sources
CPSF1 Is Co-Amplified with MYC but Is Independently Associated with Alternative Polyadenylation in Cancer [PDF]
BiologyCleavage and polyadenylation (CPA) is a co-transcriptional mRNA processing mechanism that is central to mRNA and protein function. Dysregulation of CPA is widespread in cancer, promotes oncogenic programs, and affects patient outcomes.
Abdulrahman A. Alahmari
doaj +2 more sources
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. [PDF]
Genes & Development, 1995 Cleavage-polyadenylation specificity factor (CPSF) is a multisubunit protein that plays a central role in 3' processing of mammalian pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA ...
Kanneganti Murthy, James L. Manley
openalex +2 more sources
Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein [PDF]
Genes to Cells, 2005 Ligand‐bound receptors of the Transforming Growth Factor‐β (TGF‐β) family promote the formation of complexes between Smad proteins that subsequently accumulate in the nucleus and interact there with other transcriptional regulators, leading to modulation of target gene expression.
Clara Collart +9 more
semanticscholar +6 more sources
Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells. [PDF]
PLoS PathogensHuman immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV ...
Daphne Cornish +12 more
doaj +2 more sources
International Journal of Cancer, 2002 AbstractTo identify CTL‐directed antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLA‐A2‐restricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen holding peptides capable of inducing CTLs.
Yoshiaki Maeda +9 more
semanticscholar +4 more sources
Revisiting CPSF30-mediated alternative polyadenylation in Arabidopsis thaliana. [PDF]
PLoS ONEAlternative polyadenylation (APA) is an important contributor to the regulation of gene expression in plants. One subunit of the complex that cleaves and polyadenylates mRNAs in the nucleus, CPSF30 (for the 30 kD subunit of the mammalian Cleavage and ...
Guijie Hao +4 more
doaj +2 more sources