Results 21 to 30 of about 22,447 (214)

A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]

, 2017
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun, Guo, Yibin, Huang, Chunliu, Huang, Shanshan, Huang, Weijun, Huang, Xi, Jia, Jie, Ming, Siqi, Shi, Junjie, Shi, Yongsheng, Wu, Xingui, Xiang, Andy Peng, Yao, Chengguo, Zhang, Rui, Zhao, Wei   +14 more
core   +1 more source

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

eLife, 2017
3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity ...
Marcello Clerici, Marco Faini, Ruedi Aebersold, Martin Jinek   +3 more
doaj   +1 more source

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source

Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]

, 2019
Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie, Marconi, Marco, Ortega-Campayo, Víctor, Rodríguez-Romero, Julio, Sesma, Ane, Wilkinson, Mark D.   +5 more
core   +1 more source

Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]

, 2002
Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T., Dheur, Sonia, Hector, Ronald E., Minvielle‐Sebastia, Lionel, Non, Priscilla J., Nykamp, Keith R., Swanson, Maurice S., Urbinati, Carl R., Wilson, Scott M.   +8 more
core   +3 more sources

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Molecular Cancer, 2022
Background Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear.
Xue Wang, Han Cheng, Jing Zhao, Jiuming Li, Ying Chen, Kaisa Cui, Lu Tian, Jia Zhang, Chaoqun Li, Shengbai Sun, Yuyang Feng, Surui Yao, Zehua Bian, Shenglin Huang, Bojian Fei, Zhaohui Huang   +15 more
doaj   +1 more source

m6A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Molecular Therapy: Nucleic Acids, 2022
Androgen receptor splice variant 7 (AR-v7), a constitutively active transcription factor, plays a crucial role in the progression of castration-resistant prostate cancer (CRPC).
Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha   +8 more
doaj  

A polyadenylation factor subunit implicated in regulating oxidative signaling in Arabidopsis thaliana. [PDF]

PLoS ONE, 2008
BACKGROUND: Plants respond to many unfavorable environmental conditions via signaling mediated by altered levels of various reactive oxygen species (ROS).
Jingxian Zhang, Balasubramanyam Addepalli, Kil-Young Yun, Arthur G Hunt, Ruqiang Xu, Suryadevara Rao, Qingshun Q Li, Deane L Falcone   +7 more
doaj   +1 more source

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length

Cell Reports, 2012
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3′ untranslated regions, the latter typically associated with higher transcript stability and increased protein production.
Georges Martin, Andreas R. Gruber, Walter Keller, Mihaela Zavolan   +3 more
doaj   +1 more source