Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma [PDF]
Frontiers in Cell and Developmental Biology, 2021 Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism required for cleavage and polyadenylation (CPA) of the 3′ untranslated region (3′ UTR) of mRNAs. Several aberrant APA events have been reported in hepatocellular carcinoma (HCC). However, the regulatory mechanisms underlying APA remain unclear. In this study, we
Shi‐Lu Chen +8 more
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Cleavage and polyadenylation specific factor 6 is required for HIV latency reversal
Journal of Virus Eradication, 2019 Yuanyuan Zheng +4 more
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Cleavage and polyadenylation specific factor 6 (CPSF6); cyclophilin A (CYPA; PPIA) [PDF]
Science-Business eXchange, 2013 openalex +3 more sources
Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In Vitro [PDF]
International Journal of Molecular Sciences, 2023 Potential oncogene cleavage and polyadenylation specific factor 4 (CPSF4) has been linked to several cancer types. However, little research has been conducted on its function in prostate cancer (PCa). In benign, incidental, advanced, and castrate resistant PCa (CRPCa) patient samples, protein expression of CPSF4 was examined on tissue microarray (TMAs)
Muhammad Choudhry +3 more
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Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer [PDF]
Discover OncologyBackground Bladder cancer (BC) remains a prevalent malignancy worldwide, with rising incidence rates each year. Despite progress in therapeutic strategies, many patients suffer recurrence or progression, emphasizing the urgent need for novel prognostic ...
Zhiyang Ma +5 more
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The crystal structure of human cleavage and polyadenylation specific factor‐5 reveals a dimeric Nudix protein with a conserved catalytic site [PDF]
Proteins: Structure, Function, and Bioinformatics, 2008 The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site Lionel Tresaugues,1y Pal Stenmark,1,2y Herwig Schuler,1y Susanne Flodin, Martin Welin, Tomas Nyman, Martin Hammarstrom, Martin Moche, Susanne Graslund, and Par Nordlund* 1Department of Medical Biochemistry and ...
L. Tresaugues +9 more
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Construction and characterization of coronavirus nonstructural protein 3-host protein interaction networks unravel an important role of cleavage and polyadenylation specificity factor 6 in regulation of viral RNA replication [PDF]
bioRxivXinxin Sun +7 more
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Nucleic Acids Research, 1995 3'-processing of mRNA precursors depends on several protein factors. One of them, cleavage and polyadenylation specificity factor (CPSF) is required for the cleavage of the mRNA precursor or as well as for the tail elongation reaction. We have obtained complementary DNA encoding the 160 kDa subunit, which had previously been shown to interact with the ...
Andreas Jenny, Walter Keller
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Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.
Journal of Biological Chemistry, 1992 Kanneganti Murthy, James L. Manley
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Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
eLife, 2022 3′ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 MDa multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation. In mammals, the cleavage and polyadenylation specificity factor (CPSF)
Lena Maria Muckenfuss +4 more
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