Results 41 to 50 of about 15,002 (190)

m6A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Molecular Therapy: Nucleic Acids, 2022
Androgen receptor splice variant 7 (AR-v7), a constitutively active transcription factor, plays a crucial role in the progression of castration-resistant prostate cancer (CRPC).
Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha   +8 more
doaj   +1 more source

Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin

Open Biology, 2023
Eukaryotic pre-mRNA is processed by a large multiprotein complex to accurately cleave the 3′ end, and to catalyse the addition of the poly(A) tail.
Stéphane Thore, Finaritra Raoelijaona, Vincent Talenton, Sébastien Fribourg, Cameron D. Mackereth   +4 more
doaj   +1 more source

CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors

Biomolecules, 2022
In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the ...
Joana Guiro, Mathias Fagbemi, Michael Tellier, Justyna Zaborowska, Stephanie Barker, Marjorie Fournier, Shona Murphy   +6 more
doaj   +1 more source

HIV Capsid and Integration Targeting

Viruses, 2021
Integration of retroviral reverse transcripts into the chromosomes of the cells that they infect is required for efficient viral gene expression and the inheritance of viral genomes to daughter cells.
Alan N. Engelman
doaj   +1 more source

Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer

Pharmacological Research, 2022
Sorafenib, a multikinase inhibitor, is the first-line agent for advanced liver cancer. Sorafenib strongly inhibits both cell proliferation and tumour angiogenesis. However, the development of drug resistance hampers its anticancer efficacy.
Liyun Zheng, Shiji Fang, Aifang Chen, Weiqian Chen, Enqi Qiao, Minjiang Chen, Gaofeng Shu, Dengke Zhang, Chunli Kong, Qiaoyou Weng, Suqin Xu, Zhongwei Zhao, Jiansong Ji   +12 more
doaj   +1 more source

Upregulation of Cleavage and Polyadenylation Specific Factor 4 in Lung Adenocarcinoma and Its Critical Role for Cancer Cell Survival and Proliferation

PLoS ONE, 2013
Cleavage and polyadenylation specific factor 4 (CPSF4), a member of CPSF complex, plays a key role in mRNA polyadenylation and mRNA 3' ends maturation. However, its possible role in lung cancer pathogenesis is unknown. In this study, we investigated the biological role and clinical significance of CPSF4 in lung cancer growth and survival and elucidated
Wangbing Chen, Wei Guo, Mei Li, Dingbo Shi, Yun Tian, Zhenlin Li, Jingshu Wang, Lingyi Fu, Xiangsheng Xiao, Quentin Qiang Liu, Shusen Wang, Wenlin Huang, Wuguo Deng   +12 more
openalex   +5 more sources

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

eLife, 2017
3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity ...
Marcello Clerici, Marco Faini, Ruedi Aebersold, Martin Jinek   +3 more
doaj   +1 more source

Integration of developmental and environmental signals via a polyadenylation factor in Arabidopsis. [PDF]

PLoS ONE, 2014
The ability to integrate environmental and developmental signals with physiological responses is critical for plant survival. How this integration is done, particularly through posttranscriptional control of gene expression, is poorly understood ...
Man Liu, Ruqiang Xu, Carrie Merrill, Liwei Hong, Carol Von Lanken, Arthur G Hunt, Qingshun Q Li   +6 more
doaj   +1 more source

CPSF30 at the Interface of Alternative Polyadenylation and Cellular Signaling in Plants

Biomolecules, 2015
Post-transcriptional processing, involving cleavage of precursor messenger RNA (pre mRNA), and further incorporation of poly(A) tail to the 3' end is a key step in the expression of genetic information.
Manohar Chakrabarti, Arthur G. Hunt
doaj   +1 more source

Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length

Cell Reports, 2012
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3′ untranslated regions, the latter typically associated with higher transcript stability and increased protein production.
Georges Martin, Andreas R. Gruber, Walter Keller, Mihaela Zavolan   +3 more
doaj   +1 more source