Results 51 to 60 of about 22,447 (214)

Specificity factors in cytoplasmic polyadenylation [PDF]

, 2013
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development.
Afonina, Alarcon, Andres-Aguayo, Arumugam, Ascano, Aslam, Atkins, Atkins, Baines, Balagopal, Ballantyne, Bardwell, Barkoff, Barkoff, Barnard, Barnard, Bazzini, Belloc, Belloc, Benoit, Berger-Sweeney, Bermudez, Berndt, Bestman, Bestman, Bethune, Bilger, Bouvet, Bouvrette, Bouvrette, Brawerman, Brook, Brook, Burgess, Burgess, Burns, Burns, Bushell, Campbell, Campbell, Cao, Cao, Cao, Castagnetti, Cervello, Chan, Chang, Charlesworth, Charlesworth, Charlesworth, Charlesworth, Charlesworth, Chen, Chen, Chen, Cheng, Cheng, Chicoine, Choi, Clarke, Cogswell, Coll, Collier, Cooke, Costa, Craig, Darnell, Darnell, Dasgupta, De Moor, De Moor, Derry, Dettwiler, Di Giammartino, Dickson, Dickson, Didiot, Djuranovic, Du, Eckmann, Eckmann, Edwards, Eiring, Eliscovich, Ernoult-Lange, Ezeh, Fabian, Fan, Ferby, Fernandez-Miranda, Fox, Frank-Vaillant, Friend, Fu, Gavin, Gebauer, Gebauer, Gonzales, Gravina, Groisman, Groisman, Groisman, Groisman, Gunter, Guzeloglu-Kayisli, Guzeloglu-Kayisli, Hafer, Hake, Hake, Hodgman, Hoog, Hosoda, Hosoda, Houseley, Hu, Huang, Huang, Huang, Huarte, Hägele, Igea, Imai, Jenkins, Ji, Jin, Johnson, Jones, Juge, Kan, Kashiwabara, Kashiwabara, Kashiwabara, Katoh, Kaufmann, Kawahara, Keady, Keleman, Kerwitz, Kiessling, Kim, Kim, Kim, Kim, Kim, Kojima, Kolev, Kondrashov, Kosaka, Kraus, Kruttner, Kuehn, Kuehner, Kuhn, Kundel, Kuo, Kuo, Kwak, Kwak, Laishram, Laishram, Lee, Li, Lin, Lin, Luitjens, Lutz, Ma, Maisonneuve, Makeyev, Mandel, Martin, Martineau, Martinez, Martinson, Masuda, Maton, McEvoy, McGrew, McGrew, McPheeters, Meijer, Meijer, Meijer, Mellman, Mellman, Mendez, Mendez, Mendez, Menon, Millevoi, Moore, Moretti, Mukherjee, Nagaike, Nagaoka, Nairismagi, Nakahata, Nakahata, Nakahata, Nakanishi, Nakanishi, Nakel, Novoa, Okano, Oruganty-Das, Osborne, Ostareck-Lederer, Padmanabhan, Paffenholz, Paillard, Paillard, Papin, Paris, Paris, Pavlopoulos, Pederson, Peng, Piazzon, Pique, Preker, Proudfoot, Qu, Quenault, Racki, Radford, Rattenbacher, Reverte, Reverte, Reynolds, Roretz, Rouhana, Ryan, Rybarska, Sagata, Sagawa, Sakakibara, Sallés, Sasayama, Schmid, Schoenberg, Seli, Setoyama, Shcherbik, Sheets, Sheets, Shi, Shinojima, Si, Si, Si, Simon, Simon, Simon, Slevin, Soucek, Standart, Stebbins-Boaz, Suh, Suh, Suzuki, Takagaki, Takeda, Tan, Tay, Tay, Tay, Teplova, Theis, Tian, Todaro, Topalian, Tran, Tucker, Udagawa, van, Vardy, Vassalli, Vessey, Villalba, Vishnu, Vogler, Wang, Wang, Wang, Wang, Wang, Watanabe, Weill, Weiss, Wells, Wilt, Wiszniak, Wong, Wong, Wong, Wreden, Wu, Wu, Wu, Wu, Yang, Yang, Yang, Ye, Yen, Yeo, Zalfa, Zearfoss, Zeng, Zhao, Zhong, Zhuang   +311 more
core   +2 more sources

Global analysis of CPSF2-mediated alternative splicing: Integration of global iCLIP and transcriptome profiling data

Genomics Data, 2015
Alternative splicing is a key mechanism for generating proteome diversity, however the mechanisms regulating alternative splicing are poorly understood.
Ashish Misra, Jianhong Ou, Lihua Julie Zhu, Michael R. Green   +3 more
doaj   +1 more source

The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3′-end processing of animal histone mRNAs [PDF]

, 2017
Metazoan replication-dependent histone pre-mRNAs undergo a unique 3′-cleavage reaction which does not result in mRNA polyadenylation. Although the cleavage site is defined by histone-specific factors (hairpin binding protein, a 100-kDa zinc-finger ...
Azzouz, Teldja N., Barabino, Silvia M. L., Kleinschmidt, Nicole, Pillai, Ramesh S., Ruepp, Marc-David, Schümperli, Daniel, Vivarelli, Silvia   +6 more
core  

Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions [PDF]

, 2007
3' untranslated regions (3' UTRs) contain binding sites for many regulatory elements, and in particular for microRNAs (miRNAs). The importance of miRNA-mediated post-transcriptional regulation has become increasingly clear in the last few years.
Caselle, Michele, Cora, Davide, Di Cunto, Ferdinando, Provero, Paolo   +3 more
core   +4 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer

Pharmacological Research, 2022
Sorafenib, a multikinase inhibitor, is the first-line agent for advanced liver cancer. Sorafenib strongly inhibits both cell proliferation and tumour angiogenesis. However, the development of drug resistance hampers its anticancer efficacy.
Liyun Zheng, Shiji Fang, Aifang Chen, Weiqian Chen, Enqi Qiao, Minjiang Chen, Gaofeng Shu, Dengke Zhang, Chunli Kong, Qiaoyou Weng, Suqin Xu, Zhongwei Zhao, Jiansong Ji   +12 more
doaj  

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

eLife, 2019
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
David Alejandro Bejarano, Ke Peng, Vibor Laketa, Kathleen Börner, K Laurence Jost, Bojana Lucic, Bärbel Glass, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich   +9 more
doaj   +1 more source

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. [PDF]

, 2015
Journal ArticleResearch Support, Non-U.S. Gov't© The Author(s) 2011. This article is published with open access at Springerlink.comAIMS/HYPOTHESIS: Intronic single nucleotide polymorphisms within the transcription factor 7-like 2 (TCF7L2) gene are ...
Da Silva Xavier, G, Harries, LW, Locke, JM, Rutter, GA   +3 more
core   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source