Results 51 to 60 of about 15,002 (190)

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Molecular Cancer, 2022
Background Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear.
Xue Wang, Han Cheng, Jing Zhao, Jiuming Li, Ying Chen, Kaisa Cui, Lu Tian, Jia Zhang, Chaoqun Li, Shengbai Sun, Yuyang Feng, Surui Yao, Zehua Bian, Shenglin Huang, Bojian Fei, Zhaohui Huang   +15 more
doaj   +1 more source

A polyadenylation factor subunit implicated in regulating oxidative signaling in Arabidopsis thaliana. [PDF]

PLoS ONE, 2008
BACKGROUND: Plants respond to many unfavorable environmental conditions via signaling mediated by altered levels of various reactive oxygen species (ROS).
Jingxian Zhang, Balasubramanyam Addepalli, Kil-Young Yun, Arthur G Hunt, Ruqiang Xu, Suryadevara Rao, Qingshun Q Li, Deane L Falcone   +7 more
doaj   +1 more source

Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene

Scientific Reports, 2017
Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li, Zhaoyang Liu, Wenjia Lu, Man Liu   +3 more
doaj   +1 more source

snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis. [PDF]

PLoS Biology, 2016
Uridine-rich small nuclear RNAs (snRNAs) are the basal components of the spliceosome and play essential roles in splicing. The biogenesis of the majority of snRNAs involves 3' end endonucleolytic cleavage of the nascent transcript from the elongating DNA-
Yunfeng Liu, Shengjun Li, Yuan Chen, Athen N Kimberlin, Edgar B Cahoon, Bin Yu   +5 more
doaj   +1 more source

Dual R108K and G189D Mutations in the NS1 Protein of A/H1N1 Influenza Virus Counteract Host Innate Immune Responses

Viruses, 2021
Influenza A viruses (IAV) modulate host antiviral responses to promote growth and pathogenicity. Here, we examined the multifunctional IAV nonstructural protein 1 (NS1) of influenza A virus to better understand factors that contribute to viral ...
Meng-Ting Huang, Sen Zhang, Ya-Nan Wu, Wei Li, Yu-Chang Li, Chang-Shuai Zhou, Xiao-Ping Kang, Tao Jiang   +7 more
doaj   +1 more source

Archaeal Tuc1/Ncs6 homolog required for wobble uridine tRNA thiolation is associated with ubiquitin-proteasome, translation, and RNA processing system homologs. [PDF]

PLoS ONE, 2014
While cytoplasmic tRNA 2-thiolation protein 1 (Tuc1/Ncs6) and ubiquitin-related modifier-1 (Urm1) are important in the 2-thiolation of 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) at wobble uridines of tRNAs in eukaryotes, the biocatalytic roles and ...
Nikita E Chavarria, Sungmin Hwang, Shiyun Cao, Xian Fu, Mary Holman, Dina Elbanna, Suzanne Rodriguez, Deanna Arrington, Markus Englert, Sivakumar Uthandi, Dieter Söll, Julie A Maupin-Furlow   +11 more
doaj   +1 more source

Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis. [PDF]

PLoS ONE, 2009
RNA silencing functions as an important antiviral defense mechanism in a broad range of eukaryotes. In plants, biogenesis of several classes of endogenous small interfering RNAs (siRNAs) requires RNA-dependent RNA Polymerase (RDR) activities.
Xiaopeng Qi, Forrest Sheng Bao, Zhixin Xie   +2 more
doaj   +1 more source

G-Quadruplex DNA and Other Non-Canonical B-Form DNA Motifs Influence Productive and Latent HIV-1 Integration and Reactivation Potential

Viruses, 2022
The integration of the HIV-1 genome into the host genome is an essential step in the life cycle of the virus and it plays a critical role in the expression, long-term persistence, and reactivation of HIV expression. To better understand the local genomic
Hannah O. Ajoge, Hinissan P. Kohio, Ermela Paparisto, Macon D. Coleman, Kemen Wong, Sean K. Tom, Katie L. Bain, Charles C. Berry, Eric J. Arts, Stephen D. Barr   +9 more
doaj   +1 more source

Novel snail1 target proteins in human colon cancer identified by proteomic analysis. [PDF]

PLoS ONE, 2010
The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT), a process responsible for the acquisition of invasiveness during tumorigenesis.
María Jesús Larriba, Juan Casado-Vela, Natalia Pendás-Franco, Raúl Peña, Antonio García de Herreros, María Teresa Berciano, Miguel Lafarga, J Ignacio Casal, Alberto Muñoz   +8 more
doaj   +1 more source

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

Microorganisms, 2021
Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures.
Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille, Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain, Charles E. Mowbray, Stéphanie Braillard, Marc Ouellette, Louis Maes, Guy Caljon   +12 more
doaj   +1 more source