Results 71 to 80 of about 22,447 (214)

Past, present, and future strategies for detecting and quantifying circular RNA variants

The FEBS Journal, EarlyView.
Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley   +1 more source

Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells. [PDF]

PLoS ONE, 2012
BACKGROUND: In vertebrates, poly(A) binding protein (PABP) is known to exist in five different isoforms. PABPs are primarily cytosolic with the exception of the nuclear PABP (PABPN1), which is located in the nucleus.
Rumpa Biswas Bhattacharjee, Jnanankur Bag   +1 more
doaj   +1 more source

ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervious system

, 2015
Alternative polyadenylation (APA) has been implicated in a variety of developmental and disease processes. A particularly dramatic form of APA occurs in the developing nervous system of flies and mammals, whereby various developmental genes undergo ...
Esposito, E., Hilgers, V., Jun, D., Lemke, S., Levine, M., Lotz, T., Ng, S., Oktaba, K., Zhang, W.   +8 more
core   +1 more source

Molecular dissection of mRNA poly(A) tail length control in yeast [PDF]

, 2008
In eukaryotic cells, newly synthesized mRNAs acquire a poly(A) tail that plays several fundamental roles in export, translation and mRNA decay. In mammals, PABPN1 controls the processivity of polyadenylation and the length of poly(A) tails during de novo
Afonina, Amrani, Anderson, Baer, Baer, Bienroth, Bouvet, Brown, Butler, Cartegni, De Vries, Deardorff, Dheur, Dichtl, Dunn, Edmonds, Florence Voisinet-Hakil, Ghisolfi, Hatfield, Hector, Hilleren, Hosoda, Kaufmann, Keller, Kelly, Kerwitz, Kiledjian, Kuhn, Lee, Lingner, Lionel Minvielle-Sebastia, Mandel, Marfatia, Martin, McBride, Mears, Meyer, Minvielle-Sebastia, Minvielle-Sebastia, Minvielle-Sebastia, Nicolas Viphakone, Perreault, Preker, Preker, Rigaut, Sachs, Sachs, Takagaki, Wahle, Wahle, Wahle, Weiss, Winstall, Zhao   +53 more
core   +4 more sources

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

Microbiology Spectrum, 2021
To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved.
Julie Janssens, Jolien Blokken, Yulia Lampi, Flore De Wit, Irena Zurnic Bonisch, Ivan Nombela, Paulien Van de Velde, Barbara Van Remoortel, Rik Gijsbers, Frauke Christ, Zeger Debyser   +10 more
doaj   +1 more source

A global function for transcription factors in assisting RNA polymerase II termination. [PDF]

, 2017
The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core   +1 more source

N6‐methyladenosine RNA modification regulates light intensity‐dependent terpenoid biosynthesis in Schizonepeta tenuifolia

Plant Biotechnology Journal, EarlyView.
Summary Schizonepeta tenuifolia Briq. (S. tenuifolia) is a traditional Chinese medicinal plant widely used to treat colds, fever and respiratory diseases. Volatile oils including the monoterpenoids limonene, pulegone and menthone are major constituents of S. tenuifolia that determine its medicinal value and consumer popularity.
Man Zhang, Qingyi Zhang, Zhirong Chen, Shuqi Wen, Yinhong Feng, Sujuan Duan, Hong‐Bin Wang, Hong‐Lei Jin   +7 more
wiley   +1 more source

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

EMBO Molecular Medicine, 2017
Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans.
Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, Bastien Touquet, Rose‐Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed‐Ali Hakimi   +14 more
doaj   +1 more source

Exploring the untapped potential of single‐cell and spatial omics in plant biology

New Phytologist, Volume 247, Issue 3, Page 1098-1116, August 2025.
Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley   +1 more source