Results 81 to 90 of about 22,447 (214)

Alterations of the transcriptome of Sulfolobus acidocaldarius by exoribonuclease aCPSF2.

PLoS ONE, 2013
Recent studies identified a 5´ to 3´ exoribonuclease termed Sso-RNase J in the crenarchaeon Sulfolobus solfataricus (Sso), which has been reclassified to the aCPSF2 (archaeal cleavage and polyadenylation specificity factor 2) group of β-CASP proteins. In
Birgit Märtens, Fabian Amman, Salim Manoharadas, Lukas Zeichen, Alvaro Orell, Sonja-Verena Albers, Ivo Hofacker, Udo Bläsi   +7 more
doaj   +1 more source

Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors [PDF]

, 2016
Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC complex, composed of Rhino, Deadlock and Cutoff (Cuff) bind chromatin of dual-strand ...
Aravin, Alexei A., Chen, Yung-Chia Ariel, Fejes Toth, Katalin, Laver, John D., Le Thomas, Adrien, Li, Sisi, Lipshitz, Howard D., Luo, Yicheng, Ninova, Maria, Patel, Dinshaw J., Rozhavskaya, Ekaterina, Smibert, Craig A., Stuwe, Evelyn, Vempati, Sivani   +13 more
core   +2 more sources

Advancing Design Strategy of PROTACs for Cancer Therapy

MedComm, Volume 6, Issue 7, July 2025.
A comprehensive update on the PROTAC design, and highlighting the role of artificial intelligence in the PROTAC design for cancer therapy. ABSTRACT Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics.
Hang Luo, Yuan Tian, Razack Abdullah, Baoting Zhang, Yuan Ma, Ge Zhang   +5 more
wiley   +1 more source

A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation [PDF]

, 2016
Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recently linked to proliferative states and cancer.
Belmadani, Manuel, Ghosh, Souvik, Gruber, Andreas J., Gruber, Andreas R., Keller, Walter, Martin, Georges, Schmidt, Ralf, Zavolan, Mihaela   +7 more
core   +1 more source

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

The Rift Valley Fever virus protein NSm and putative cellular protein interactions

Virology Journal, 2012
Rift Valley Fever is an infectious viral disease and an emerging problem in many countries of Africa and on the Arabian Peninsula. The causative virus is predominantly transmitted by mosquitoes and high mortality and abortion rates characterize outbreaks
Engdahl Cecilia, Näslund Jonas, Lindgren Lena, Ahlm Clas, Bucht Göran   +4 more
doaj   +1 more source

PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Polypyrimidine tract binding protein 1 (PTBP1) belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and is a widely studied RNA‐binding protein involved in regulating mRNA splicing, stability, localization, and translation. In addition, PTBP1 can participate in various non‐coding RNA action processes and affect tumorigenesis ...
Chengdong Ji, Jing Zhu, Xiaochen Hou, Chen Zhou, Jiumei Zhao, Xiang Zheng, Yu Tang   +6 more
wiley   +1 more source

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma [PDF]

, 2021
Shi‐Lu Chen, Zhongxu Zhu, Yang Xia, Lili Liu, Yangfan He, Mingming Yang, Xin–Yuan Guan, Xin Wang, Jingping Yun   +8 more
openalex   +1 more source

Reciprocal Effects of Splicing and Polyadenylation on Human Immunodeficiency Virus Type 1 Pre-mRNA Processing [PDF]

, 1996
Insertion of a functional splicing cassette into a construct containing the HIV-1 poly(A) site followed by the adenovirus L3 poly(A) site results in both specific stimulation of 3′ end processing at the HIV-1 site and an increase in the steady-state ...
Imperiale, Michael J., Scott, Jeannine M.   +1 more
core   +1 more source