Results 191 to 200 of about 4,811 (202)

CLEC-2 is required for the activation of mouse platelets by bacterial DNA mimetics

, 2015
Céline Delierneux, Alexandre Hego, Christelle Lecut, Maud Vandereyken, Lucia Musumeci, Souad Rahmouni, Vincent Bours, Patrizio Lancellotti, Cécile Oury   +8 more
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PKN2 signalling induces stromal cell protrusions to preserve lymph node structural integrity

Acton S, Millward L, Benjamin A, Makris S, Horsnell H, Menezes S, Shewring D, Tape C, Saez P, Cameron A, de Winde C.   +10 more
europepmc   +1 more source

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Platelet CLEC-2: Roles Beyond Hemostasis

Seminars in Thrombosis and Hemostasis, 2017
AbstractC-type lectin-like receptor 2 (CLEC-2) has been identified on the surface of platelets as a receptor for a platelet activating snake venom, rhodocytin/aggretin. CLEC-2 belongs to a C-type lectin superfamily and binds to a sialoglycoprotein, podoplanin, in vivo.
Katsue, Suzuki-Inoue, Nagaharu, Tsukiji, Toshiaki, Shirai, Makoto, Osada, Osamu, Inoue, Yukio, Ozaki   +5 more
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CLEC-2-Induced Signaling in Blood Platelets

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2018
Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic cells in lymph nodes, kidney podocytes and by cells of certain tumors.
A A, Martyanov, V N, Kaneva, M A, Panteleev, A N, Sveshnikova   +3 more
openaire   +2 more sources

Platelet CLEC-2 and podoplanin in cancer metastasis

Thrombosis Research, 2012
It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence linking platelets to cancer progression.
Kate L, Lowe, Leyre, Navarro-Nunez, Stephen P, Watson   +2 more
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RACK1 associates with CLEC-2 and promotes its ubiquitin–proteasome degradation

Biochemical and Biophysical Research Communications, 2009
CLEC-2 is a C-type lectin-like receptor and plays an important role in platelet activation. Snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin are identified as ligands for CLEC-2 and function as stimulators in platelet activation.
Yuanyuan, Ruan, Liang, Guo, Ying, Qiao, Yi, Hong, Lei, Zhou, Linlin, Sun, Lijing, Wang, Haiyan, Zhu, Lan, Wang, Xiaojing, Yun, Jianhui, Xie, Jianxin, Gu   +11 more
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CLEC-2

2016
Anil Chalisey, Thomas Hiron, Angharad E. Fenton-May, Christopher A. O’Callaghan   +3 more
openaire   +1 more source

CLEC-2

2012
Angharad E. Fenton-May, Christopher A. O’Callaghan   +1 more
openaire   +1 more source

GPVI and CLEC-2

2013
Alice Y. Pollitt, Craig E. Hughes, Steve P. Watson   +2 more
openaire   +1 more source

GPVI and CLEC-2

2019
Elizabeth J. Haining, Phillip L.R. Nicolson, Marie-Blanche Onselaer, Natalie S. Poulter, Julie Rayes, Mark R. Thomas, Steve P. Watson   +6 more
openaire   +1 more source