Results 61 to 70 of about 2,528 (212)

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Farouk Boudou, Alaeddine Berkane, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, Brian A. Murray, Mikhael Bechelany, Ahmed Barhoum   +7 more
wiley   +1 more source

Lignans and clerodane diterpenoids from Tinospora sinensis

RSC Advances, 2020
Four previously undescribed compounds including a tetrahydrofuran lignan ( 1 ), a 7,9′-dinorlignan glucoside ( 2 ), and two clerodane diterpenoid glucosides ( 3–4 ), together with 18 known compounds were isolated ...
Chumao Wen, Jun Li, Xiaoshi Xu, Qingqing Li, Yitong Li, Yu Chen, Guangzhong Yang   +6 more
openaire   +3 more sources

The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways

Journal of Oral Pathology &Medicine, Volume 55, Issue 1, Page 61-72, January 2026.
ABSTRACT Background 16‐hydroxycleroda‐3,13‐dien‐15,16‐olide (HCD), a compound isolated from Polyalthia longifolia var. pendula, has been identified as a PI3K inhibitor. P. longifolia var. pendula is recognized for its diverse pharmacological properties, including antimicrobial, hypotensive, anti‐inflammatory, and cytotoxic activities.
Leong‐Perng Chan, Ya‐Ping Tseng, Hui‐Ching Wang, Chen‐Yu Chien, Che‐Wei Wu, Ling‐Feng Wang, Tung‐Wen Yen, Po‐Chun Wang, Chih‐Chuang Liaw, Chia‐Hua Liang   +9 more
wiley   +1 more source

A Clerodane Diterpene and other Constituents of Clerodendron inerme

, 1990
new clerodane diterpene clerodermic acid was isolated from Clerodendron inerme and the structure deduced from spectral data. The known compounds friedelin, S-hydroxy-7,4’-dimethoxyflavone, salvigenin, acacetin and apigenin were also ...
Saha, Chitta R, Chaudhuri, Chandana, Pradeep K. Dutta, Dutta , Pradeep K, Satyesh C. Pakrashi, Chandana Chaudhuri, Achari, Basudeb, Pakrashi, Satyesh C, Basudeb Achari, Chitta R. Saha   +9 more
core   +1 more source

Exploring the Antiproliferative Activity of Flavolignans From the Leaves of Casearia arborea (Salicaceae)

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT The Casearia genus (Salicaceae) is well known as a source of natural antitumor prototypes, as described for clerodane diterpenes. In this way, the dichloromethane phase from leaves of Casearia arborea was phytochemically evaluated in liquid chromatography coupled to high‐resolution mass spectrometry, furnishing flavonoid, flavolignan, and ...
Augusto L. Santos, Mariana T. Rodrigues, Ana Paula Michelli, Rodrigo E. Tamura, Ileana G. S. de Rubió, Marisi G. Soares, Marcelo J. P. Ferreira, Patricia Sartorelli   +7 more
wiley   +1 more source

Eperua oleifera Ducke (Fabaceae) Oilresin Chemical Composition and the Isolation of a Natural Diterpenic Acid Methyl Ester

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Eperua oleifera (Fabaceae) oilresin presents not only diterpenic acids, but also diterpenic acid methyl ester. ABSTRACT Eperua oleifera Ducke, commonly known as “copaíba‐jacaré,” produces oilresins traditionally used in folk medicine for wound healing and as antifungal and antibacterial agents, similar to those of Copaifera species.
Rayssa Ribeiro, Henrique M. G. Pereira, Alvicler Magalhães, Fernando Hallwass, Monica C. Padilha, Valdir F. Veiga‐Junior   +5 more
wiley   +1 more source

Identificação de diterpenos clerodânicos em diferentes órgãos de Casearia sylvestris Swartz

Revista de Ciências Farmacêuticas Básica e Aplicada, 2010
<p align="justify">Casearia sylvestris Swartz (Salicaceae) é uma espécie vegetal arbórea ou arbustiva, disseminada pelo território brasileiro e bastante utilizada em nossa medicina popular.
Elisângela Simões de Carvalho, André Gonzaga dos Santos, Alberto José Cavalheiro   +2 more
doaj  

Clerodane Diterpenes from Species: Distribution and a Compilation of their C NMR Spectral Data

Natural Product Communications, 2006
The present work is a review of the literature of clerodane diterpenes from Croton species. It contains a compilation of 13 C NMR data of 83 of these diterpenoids and their biological activities.
Sebastião F. Palmeira Jünior, Lucia M. Conserva, José Maria Barbosa Filho   +2 more
doaj   +1 more source

Unveiling the Chemical Profile of Teucrium chamaedrys subsp. gracile (Batt.) Rech.F. dried Aerial Parts From Algeria

Chemistry &Biodiversity, Volume 22, Issue 11, November 2025.
ABSTRACT In this paper, the first phytochemical analysis on Teucrium chamaedrys subsp. gracile was reported. The dried aerial parts collected in Algeria were studied, and the analysis was conducted using different techniques: gas chromatography/mass spectrometry (GC/MS) for the fatty acid content, headspace solid‐phase microextraction‐GC‐MS for the ...
Claudio Frezza, Daniela De Vita, Chiara Dal Bosco, Khellaf Rebbas, Hamdi Bendif, Stefania Garzoli   +5 more
wiley   +1 more source