Results 51 to 60 of about 1,664 (287)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
A CLEWS CASE STUDY OF THE GAMBIA
, 2023 The Gambia is the smallest country in mainland Africa with a total land area of 10,200 km2 and a population of 2.7 million people as 0f 2023. The country has a tiny economy dominated by services which is followed by agriculture and industry.The Gambia faces challenges such as unstable electricity supply, declining precipitation rates as well as high ...
openaire +2 more sources
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
CLEW’d In: Exploring The Lived Experiences Of Leaders Performing Clinical Learning Environment Walks (CLEWs) [PDF]
, 2020 The purpose of this phenomenological study was to explore the lived experience of leadership using Clinical Learning Environment Walks (CLEWs) to ascertain the current culture of the clinical learning environment.
Hutcherson, Lisa Ingram
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The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
EXPLORING CLEWs NEXUS FOR SUSTAINABLE DEVLOPMENT GOALS (ENERGY): A CASE STUDY OF NIGERIA
, 2023 The CLEWS analysis in Nigeria identifies the current energy mix, fossil fuel dependency, renewable energy potential, land use implications, and environmental impact, and provides policy recommendations for achieving sustainable energy goals. Power Energy
Chaanda, M. S
core +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Tropical tree farming. by Andrew Radomiljac and Mandy Clews
, 1996 tag=1 data=Tropical tree farming. by Andrew Radomiljac and Mandy Clews tag=2 data=Radomiljac, Andrew%Clews, Mandy tag=3 data=Landscope, tag=4 data=11 tag=5 data=4 tag=6 data=Winter 1996 tag=7 data=23-27.
Clews, Mandy, Radomiljac, Andrew
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