Results 191 to 200 of about 1,970,447 (262)

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Exposure to high-altitude hypobaric hypoxic environment induces low-frequency hearing loss in C57BL/6J mice: Mediated by slowing down the postsynaptic electrical signal transmission speed in the cochlear-inferior colliculus auditory signaling pathway. [PDF]

PLoS One
Ren B, Zhang Q, Gan W, Yue G, Li S, Zhang X, Cao W, Tang F, Zhang Y, Guo B, Wang Y.   +10 more
europepmc   +1 more source

Click/transclick reactions in combination with CRP: 'TAD's the spirit' [PDF]

, 2014
Billiet, Stijn, De Bruycker, Kevin, Driessen, Frank, Du Prez, Filip, Goossens, Hannelore, Van Speybroeck, Veronique, Winne, Johan   +6 more
core  

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Design and Performance of an Email-Based Patient Recruitment Campaign in Primary Care Research: Formative Secondary Analysis.

JMIR Hum Factors
Vaillancourt VT, Poirier MD, Fournier A, Wong ST, Poitras ME.   +4 more
europepmc   +1 more source

Abnormal Hearing Phenotypes in "Ignorome" Knockout Mice as Predictors of Cognitive Dysfunction. [PDF]

Genes Brain Behav
Vicencio-Jimenez S, Dent ML, Lauer AM.
europepmc   +1 more source

Triazolinediones enabling click and transclick reactions [PDF]

, 2014
Billiet, Stijn, De Bruycker, Kevin, Driessen, Frank, Du Prez, Filip, Goossens, Hannelore, Houck, Hannes, Van Speybroeck, Veronique, Winne, Johan   +7 more
core   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Protocol for analyzing the microstructure of nuclear fiber layers by using structured illumination microscopy coupled with Arivis 4D. [PDF]

STAR Protoc
Guan M, Li K, Liu X, Li X, Sun Z.
europepmc   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source