Results 221 to 230 of about 1,970,447 (262)

Hierarchical Temporal Processing in the Primate Thalamocortical System: Insights from Nonlinguistic Structured Stimuli. [PDF]

Research (Wash D C)
Ye H, Song P, Xu H, Li Q, Chen Y, Zhai Y, Chang C, Bao X, Tanigawa H, Tu Z, Chen P, Zhang T, Zhang L, Zhao X, Wen W, Pérez-González D, Malmierca MS, Yu X.   +17 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Clinical Decision Support: Point-Closing Gaps Between Evidence and Practice to Mitigate Diagnostic Error. [PDF]

AJR Am J Roentgenol
Guenette JP, Lacson R.
europepmc   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Inhibition of Dermatan Sulfate Epimerase 1 by Substituted Glucuronic Acids. [PDF]

ACS Omega
Mastio R, Zuleta Sjögren I, Dahlquist J, Sundin A, Westergren-Thorsson G, Manner S, Tykesson E, Malmström A, Ellervik U.   +8 more
europepmc   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Ground truth data set of Gas Chromatography Mass Spectrometry (GCMS) analysed synthesised methylamphetamine. [PDF]

Data Brief
Puch-Solis R, Santo FT, Miller J, Ajala B, Kunalan V, Jayaram S, Daeid NN.   +6 more
europepmc   +1 more source

An interactive segmentation-based method for seismic facies annotation and segmentation. [PDF]

Sci Rep
Tian S, Tang Y, Deng F, Luo W, Wang B, Yang S.   +5 more
europepmc   +1 more source

Bioorthogonal Click Chemistry for Antibody-Free Profiling of Acetylation, Propionylation, and Butyrylation in <i>Pseudomonas aeruginosa</i> and Methicillin-Resistant <i>Staphylococcus aureus</i>. [PDF]

ACS Infect Dis
Monacchio HN, Shah RS, Montes CF, Wang GZ, Walley JW, VanDrisse CM.   +5 more
europepmc   +1 more source

Application of Droplet-Array Sandwiching Technology to Click Reactions for High-Throughput Screening. [PDF]

Micromachines (Basel)
Miyata Y, Nishimura S, Kawakami S, Higuchi Y, Konishi S.   +4 more
europepmc   +1 more source