Results 61 to 70 of about 1,402,473 (296)

Processing of Paired Click-Tone Stimulation in the Mice Inferior Colliculus

Frontiers in Physiology, 2019
The inferior colliculus (IC) is known as a neuronal structure involved in the integration of acoustic information in the ascending auditory pathway. However, the processing of paired acoustic stimuli containing different sound types, especially when they
Ningqian Wang, Minlin Lin, An Qiao, Zhongju Xiao   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Click-Ready Perfluorocarbon Nanoemulsion for 19F MRI and Multimodal Cellular Detection

, 2021
We describe an in vivo imaging probe platform that is readily modifiable to accommodate binding of different molecular targeting moieties and payloads for multimodal image generation.
Eric T. Ahrens, Hongyan Xu (29047), Adam S. Perez, Deanne Lister, Junhan Zhou (8904461), Stephen R. Adams (2381797), Eric T. Ahrens (411199), Hongyan Xu, Adam S. Perez (11681395), Junhan Zhou, Stephen R. Adams, Benjamin Leach (11681398), Deanne Lister (11681401), Angelique Y. Louie (240149), Benjamin Leach, Angelique Y. Louie   +15 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Site‐Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene‐Functionalized Monolayers

ChemistryOpen
We report the first example of self‐assembled monolayers (SAMs) incorporating a cyclobutene‐substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron‐demand Diels–Alder (IEDDA) cycloadditions. Mixed
Boone W. Evans, Kenneth N. Hipp, William D. Lambert, Wantanee Sittiwong, Rebecca Y. Lai, Patrick H. Dussault   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Phosphatidylcholine synthesis and remodeling in brain endothelial cells

Journal of Lipid Research
Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain composition.
Mohamed H. Yaghmour, Theja Sajeevan, Christoph Thiele, Lars Kuerschner   +3 more
doaj   +1 more source

Click-Ready Perfluorocarbon Nanoemulsion for ¹⁹F MRI and Multimodal Cellular Detection

, 2021
We describe an in vivo imaging probe platform that is readily modifiable to accommodate binding of different molecular targeting moieties and payloads for multimodal image generation.
Hongyan Xu (29047), Benjamin Leach (11681398), Junhan Zhou (8904461), Deanne Lister (11681401), Angelique Y. Louie (240149), Stephen R. Adams (2381797), Eric T. Ahrens (411199), Adam S. Perez (11681395)   +7 more
core   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source