Results 41 to 50 of about 1,402,473 (296)
Exoskeleton for Biofunctionality Protection of Enzymes and Proteins for Intracellular Delivery
Advanced NanoBiomed Research, 2021 Driven by the challenges to protect and restore biofunctionality of enzymes and proteins due to fluctuation of temperature, pH, and solvents, desired tolerances against the intracellular microenvironment can be gained via sheltering enzyme and proteins ...
Saikat Dutta
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Debbie Click in a Piano Recital [PDF]
, 1974 This is the program for the piano recital of Debbie Click.
Click, Debbie
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Interview with Deb Click [PDF]
, 1999 Deb Click, a Baptist pastor, describes her expirience of being ousted by the Lutheran Church, the support from her congregation and her decision not to fight the judgement.
Hitchcock, Kate, Click, Deb
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
An Assessment of the Scholarship of Teaching and Learning in Public Administration from 2009-2013 [PDF]
InSight, 2016 The acceptance of the Scholarship of Teaching and Learning (SoTL) as a legitimate form of scholarly investigation and the shape that it takes in post-secondary education are inherently discipline-specific.
Rebekkah Stuteville, Eric Click
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A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
Química Nova, 2011 The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily ...
Luiza Baptista de Oliveira Freitas +5 more
doaj +1 more source
Relationship between Development and Divorce in Iran Mansour Dayhoul , Sirous Ahmadi , Asghar Mirfardi [PDF]
پژوهشنامه مددکاری اجتماعی, 2016 The purpose of this study was to investigate the relationship between socioeconomic development and divorce in Iran during the years 1392-1396. The present research is quantitative-longitudinal and has been done by time series method.
Mansuor Dayhuol, s a, Asghar Mirfardi
doaj +1 more source