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Angewandte Chemie, 2020
A general catalytic method using Mn-porphyrin-based catalytic system is discovered that enables two different reactions (click reaction and denitrogenative annulation) affording two different classes of nitrogen heterocycles, such as 1,5-disubstituted 1 ...
Hillol Khatua +3 more
semanticscholar +1 more source
A general catalytic method using Mn-porphyrin-based catalytic system is discovered that enables two different reactions (click reaction and denitrogenative annulation) affording two different classes of nitrogen heterocycles, such as 1,5-disubstituted 1 ...
Hillol Khatua +3 more
semanticscholar +1 more source
A Photoinduced, Benzyne Click Reaction
Organic Letters, 2014The [3 + 2] cycloaddition of azides and alkynes has proven invaluable across numerous scientific disciplines for imaging, cross-linking, and site-specific labeling among many other applications. We have developed a photoinitiated, benzyne-based [3 + 2] cycloaddition that is tolerant of a variety of functional groups as well as polar, protic solvents ...
Adam W, Gann +5 more
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Optimization of Cu catalysts for nitrophenol reduction, click reaction and alkyne coupling
, 2020Earth-abundant nanocatalysts are actively searched to replace expensive noble metal catalysts for a number of essential processes. Here, Cu catalysts have been designed based on manganese oxide octahedral molecular sieve (OMS-2) supports to optimize the ...
Yu Huang +4 more
semanticscholar +1 more source
Click Reaction-Assisted Peptide Immune Checkpoint Blockade for Solid Tumor Treatment.
ACS Applied Materials and Interfaces, 2020One of the major challenges of immune checkpoint blockade (ICB) is the poor penetration of antibody for solid tumor treatment. Herein, peptides with deeper penetration capability are used to develop a click reaction-assisted peptide immune checkpoint ...
Wu-Yi Xiao +9 more
semanticscholar +1 more source
Click-Reaction-Triggered SERS Signals for Specific Detection of Monoamine Oxidase B Activity.
Analytical Chemistry, 2020Human monoamine oxidases (MAOs) play important roles in maintaining the homeostasis of biogenic amines. One of its isoforms, monoamine oxidase B (MAOB), is thought to be involved in several neurodegenerative diseases, which make the selective detection ...
Xueqiang Wu +12 more
semanticscholar +1 more source
Click reactions with functional sphingolipids
Biological Chemistry, 2018Abstract Sphingolipids and glycosphingolipids can regulate cell recognition and signalling. Ceramide and sphingosine-1-phosphate are major players in the sphingolipid pathways and are involved in the initiation and regulation of signalling, apoptosis, stress responses and infection.
Julian, Fink, Jürgen, Seibel
openaire +2 more sources
Journal of the American Chemical Society, 2019
Nanoparticles have been extensively used to deliver therapeutic drugs to tumor tissues through extravasation from a leaky vessel via enhanced permeation and retention effect (EPR, passive targeting) or targeted interaction of tumor-specific ligands ...
S. Lee +9 more
semanticscholar +1 more source
Nanoparticles have been extensively used to deliver therapeutic drugs to tumor tissues through extravasation from a leaky vessel via enhanced permeation and retention effect (EPR, passive targeting) or targeted interaction of tumor-specific ligands ...
S. Lee +9 more
semanticscholar +1 more source
Polymeric "Clickase" Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells.
Journal of the American Chemical Society, 2019Recent work has shown that polymeric catalysts can mimic some of the remarkable features of metalloenzymes by binding substrates in proximity to a bound metal center.
Junfeng Chen +6 more
semanticscholar +1 more source
Click Reactions with Nitroxides
Synthesis, 2009Copper-catalyzed azide-alkyne 1,3-dipolar cycloadditions (CuAAC) with paramagnetic azide and alkyne building blocks are described. This method provides a route to the synthesis of complex spin-labeled molecules such as amino acids, carbohydrates, drug molecules and biradicals.
Kálmán Hideg +2 more
openaire +1 more source
Kinugasa Reaction under Click Chemistry Conditions
Synlett, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A. Basak +3 more
openaire +1 more source