Results 111 to 120 of about 3,056,878 (315)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Understanding the adaptive capacity of Australian small-to-medium enterprises to climate change and variability [PDF]

, 2013
Small-to-medium enterprises (SMEs) comprise 96 per cent of all private businesses in Australia. The SME sector is the economy’s largest employer and the largest contributor to GDP.
Janina Murta, Natasha Kuruppu, Pierre Mukheibir   +2 more
core  

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Assessment of Population Exposure to Coarse and Fine Particulate Matter in the Urban Areas of Chennai, India

The Scientific World Journal, 2015
Research outcomes from the epidemiological studies have found that the course (PM10) and the fine particulate matter (PM2.5) are mainly responsible for various respiratory health effects for humans.
Ramachandran Prasannavenkatesh, Ramachandran Andimuthu, Palanivelu Kandasamy, Geetha Rajadurai, Divya Subash Kumar, Parthasarathy Radhapriya, Malini Ponnusamy   +6 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Extreme heat and climate change: adaptation in culturally and linguistically diverse (CALD) communities [PDF]

, 2013
Background: Several overseas studies have identified that people in ethnic minority groups are at greater risk during heatwaves. However, there is a paucity of information on this issue in Australia.
Peng Bi, Alana Hansen, Arthur Saniotis
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What is needed to make climate resilient development pathways planning actionable in cities?

Environmental Research Communications
Climate Resilient Development Pathways (CRDP) is a promising concept for cities to integrate climate change mitigation and adaptation to achieve sustainable development for all.
Sadie McEvoy, Gaby Langendijk, Ad Jeuken, Marjolijn Haasnoot   +3 more
doaj   +1 more source

Commentary - The Climate Change and Health Adaptation Program: Indigenous climate leaders’ championing adaptation efforts

Health Promotion and Chronic Disease Prevention in Canada, 2019
The Climate Change and Health Adaptation Program (CCHAP) is a program within the First Nations Inuit Health Branch of Indigenous Services Canada (which was previously under the responsibility of Health Canada).
Gabrielle Richards, Jim Frehs, Erin Myers, Marilyn Van Bibber   +3 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Thirsty country: climate change and drought in Australia [PDF]

, 2015
This report argues that climate change is likely making drought worse in the southeast and southwest of Australia, which are some of our most populous regions. Introduction Drought has deeply affected Australia throughout its history.
Climate Council
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