Results 91 to 100 of about 5,789,121 (307)

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Integrating Ecology and Economics in Agent‐Based Models to Support Agricultural Policy

Advanced Science, EarlyView.
Agent‐based models are valuable tools for studying social‐ecological systems in agriculture. This review maps how existing agent‐based models represent the human and natural domains of agriculture, and discusses developments in economic and ecological agent‐based modeling.
Daniel Vedder, Judith Josephin Rakowski, Lea‐Deborah Kolb, Greta Sophie Theilen‐Loges, Sebastian Lakner, Guy Pe'er   +5 more
wiley   +1 more source

Adaptive capacity management in municipalities in the Semiarid region of Brazil: Application of a composite index

Climate Risk Management
The balance between urban growth and global environmental and climate challenges, as well as their local implications, is a fundamental contemporary concern, and often neglected in government agendas at a local scale. The integration of these issues into
Yonara Claudia dos Santos, Zoraide Souza Pessoa   +1 more
doaj   +1 more source

Managing for adaptive capacity in climate-ready fisheries

Marine Policy
Climate change is expected to increase short-run shocks and extreme events in oceanic conditions. Fishery managers are considering how to design climate-ready systems that enable fishers and fishing communities to adapt to these events without jeopardizing the long-run sustainability of the ocean ecosystem.
Reimer, Matthew N, Rogers, Anthony, Sanchirico, James N   +2 more
openaire   +3 more sources

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Assessing smallholder farmers’ vulnerability to climate change and coping strategies in South Kivu Province, eastern Democratic Republic of Congo

Environmental Systems Research
It is now well established that climate changes is affecting smallholder farmers and threatening agricultural production and livelihoods in South Kivu Province, eastern Democratic Republic of Congo (DRC), due to their limited capacity to cope with ...
Pascaline Ciza Azine, Yannick Mugumaarhahama, Valence Bwana Mutwedu, Jean Mubalama Mondo, Géant Basimine Chuma, Aksanti Buchekabiri, Thomas Mutume, Espoir Mukengere Bagula, Rodrigue Basengere-Balthazar Ayagirwe, Simon Patrick Baenyi, Samy Bashizi Bacigale, Katcho Karume   +11 more
doaj   +1 more source

Interplay of traditional knowledge and adaptive capacity in climate change adaptation of small-scale fishers in central Terengganu, Malaysia

Frontiers in Marine Science
IntroductionClimate change is a major threat to small-scale fishers and coastal population of Malaysia, especially a significant population relies on the industry.
Liyana Yamin, Ting-Chun Kuo, Ting-Chun Kuo, Nazli Aziz   +3 more
doaj   +1 more source

Institutional adaptive capacity and climate change response in the Congo Basin forests of Cameroon [PDF]

, 2010
Cameroon, Congo Basin forest, Climate change, Institutions, Perception, Adaptive capacity,
Youssoufa Bele, Peach Brown, H. Carolyn, Johnson Nkem, Denis J. Sonwa, Sonwa, Denis J., Bele, Youssoufa, H. Brown, H. Carolyn Peach Brown, Denis Sonwa, Johnson Ndi Nkem, Ndi Nkem, Johnson   +10 more
core   +1 more source