Results 131 to 140 of about 467,454 (350)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

The Review Study of Environmental Education Curriculum in Climate Change Mitigation

Jurnal Presipitasi
Indonesia is a country whose geographical location is on the equator, has many islands and tropical forest areas, and is surrounded by volcanoes. Indonesia also has a high potential for natural disasters, such as volcanic eruptions, floods, tsunamis ...
Zulfia Hanum Alfi Syahr, Dian Hafit Syaifullah, Buyamin Buyamin, Novian Uticha Sally   +3 more
doaj   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Interactions within climate policyscapes: a network analysis of the electricity generation space in the United Kingdom, 1956–2022

Frontiers in Climate
The systems of policies impacting climate change mitigation are complex. Yet, to date, we have limited conceptual and empirical knowledge on the dynamics within these.
Valeria Zambianchi, Valeria Zambianchi, Katja Biedenkopf   +2 more
doaj   +1 more source

Tackling climate change through adaptation finance in the Least Developed Countries: Is the LDC Fund still fit for purpose? [PDF]

This paper considers the challenges confronting LDCs in meeting the adaptation and mitigation requirements brought on by the climate crisis and addresses the question as to whether the Least Developed Country Fund (LDCF), which is a key source of LDC ...
Davis, Junior, Tan, Celine
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Necropolicy in the Capitalocene: Australia's political ecology of death

Journal of Political Ecology
This is the Capitalocene, an age characterised by death derived from capitalism's endless accumulation, growth, and resource exploitation. In the Capitalocene, policies dedicated to climate change mitigation are intertwined with a capitalist logic ...
Kajsa Lundberg
doaj   +2 more sources

Data for: Are the drivers of support for climate change mitigation the same across EU countries? The case of Germany and Poland

, 2021
Zbigniew Bohdanowicz
openalex   +1 more source

How Harmful are Adaptation Restrictions [PDF]

The dominant assumption in economic models of climate policy remains that adaptation will be implemented in an optimal manner. There are, however, several reasons why optimal levels of adaptation may not be attainable. This paper investigates the effects
Kelly C. de Bruin, Rob B. Dellink
core  

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source