Results 141 to 150 of about 61,424 (256)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

open access: yesAdvanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen   +19 more
wiley   +1 more source

Seawater Electrolysis Enables Multipathway Climate Change Mitigation through Atmospheric Carbon Dioxide Removal, Renewable Hydrogen Production, and Cement and Concrete Decarbonization. [PDF]

open access: yesJ Am Chem Soc
Chen X   +20 more
europepmc   +1 more source

Optimized Land–Water Management Expands Afforestation Potential Under Land and Human Water‐Use Constraints

open access: yesAdvanced Science, EarlyView.
Human water demand constrains China's feasible afforestation potential more strongly than is commonly recognized, and future climate change further intensifies this limitation. Integrating land‐use optimization with water‐saving measures substantially expands feasible afforestation area and associated carbon sinks, revealing a practical pathway to ...
Binbin Huang   +5 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

open access: yesAdvanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang   +11 more
wiley   +1 more source

Overcoming heuristics that hinder people's acceptance of climate-change-mitigation technologies. [PDF]

open access: yesFront Psychol
Blöbaum A   +5 more
europepmc   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

open access: yesAdvanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu   +8 more
wiley   +1 more source

Rhizodeposition Drives One Third of Belowground Carbon Input in Agroecosystems

open access: yesAdvanced Science, EarlyView.
This study quantifies photosynthesized C allocation in the plant–soil system across six crop types: barley, wheat, maize, rice, legumes and grasses. It reports C partitioning into shoot respiration, shoot‐C, root‐C, net rhizodeposition and root‐derived CO2, providing standardized percentage averages and GPP‐derived absolute values as a robust baseline ...
Zhengjun Yan   +10 more
wiley   +1 more source

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