Results 61 to 70 of about 18,751,832 (408)

Climate Change and Climate Science [PDF]

Science, 2004
T here is a paradoxical gulf between the importance of Earth's climate and the level of public interest in it. To be sure, tornadoes, killer heat waves, and floods make the headlines, but it's important to remember that weather is not climate. Some of the public's confusion may relate to a certain failure to make that distinction, as in the occasional ...
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Chlorine/chlorine dioxide-based process for decontamination of different pesticides from drinking water resources

Desalination and Water Treatment
The removal of pesticides from drinking water sources is an important research topic. The current study was to comprehensively investigate chlorine (Cl2)/chlorine dioxide (ClO2)-based AOPs for oxidation of five pesticides.
Mohamed I. Badawy, Mohamed Eid M. Ali
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Pesticides’ low-cost removal from polluted groundwater using charcoal from “Salix mucronata” trees activated by gold nitrate

Water Science
Used pesticides result in soil pollution, which potentially seep into groundwater, posing risks to human and animal health. The current study examines the use of a new cheap material for removing four commonly used pesticides from polluted groundwater ...
Saad Mohamed Elsaid, Nabil Anwar, Mahmoud Roushdi   +2 more
doaj   +1 more source

Measuring the economic impact of climate change on crop production in the dry zone of Myanmar : a Ricardian approach [PDF]

, 2020
Myanmar is the country with the highest economic vulnerability (EV) to climate change in the Southeast Asian region. The dry zone of Myanmar occupies two-thirds of the agricultural lands and it has higher temperatures than elsewhere in the country ...
Speelman, Stijn, Tun Oo, Aung, Van Huylenbroeck, Guido   +2 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Climate change-induced shifts in the ecological niches of Parkia biglobosa (Jacq.) and Vitellaria paradoxa CF Gaertn, two species of agroforestry parks in Benin, West Africa

Trees, Forests and People
Understanding the effects of climate change on species distribution patterns is fundamental to biogeography and evolutionary ecology, especiallyfor socio-economically important agroforestry species such as Parkia biglobosa R.Br.
Chaffra Charles Yabi, Jacques Idohou Kadjogbé Ayena, Séverin Biaou, Serge Adomou, Thierry Dèhouégnon Houehanou, Gérard Nounagnon Gouwakinnou   +5 more
doaj   +1 more source

Defining the solution space to accelerate climate change adaptation [PDF]

, 2021
M Haasnoot, R Biesbroek, Judith Lawrence, V Muccione, R Lempert, B Glavovic   +5 more
openalex   +1 more source