Results 91 to 100 of about 25,986,593 (308)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Changes in West African Summer Monsoon Precipitation Under Stratospheric Aerosol Geoengineering

Earth's Future, 2020
Stratospheric aerosol geoengineering (SAG) is suggested as a potential way to reduce the climate impacts of global warming. Using simulations from the Geoengineering Large Ensemble project that employed stratospheric sulfate aerosols injection to keep ...
C. Y. Da‐Allada, E. Baloïtcha, E. A. Alamou, F. M. Awo, F. Bonou, Y. Pomalegni, E. I. Biao, E. Obada, J. E. Zandagba, S. Tilmes, P. J. Irvine   +10 more
doaj   +1 more source

Problematic Internet Use in Frontotemporal Dementia: A Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The present study investigated problematic internet use (PIU) among 61 patients with frontotemporal dementia (FTD) compared to a cohort of 354 patients with mild cognitive impairment (MCI) and Alzheimer's dementia. PIU was identified in 22.9% of FTD patients compared to only 0.8% of AD patients (p < 0.001). Behaviors included compulsive social
Daniele Urso, Giuseppe Volpe, Agnese Valguarnera, Davide Vilella, Alessandra Vitulli, Valentina Gnoni, Alessia Giugno, Eleonora Rollo, Mark D. Griffiths, Giancarlo Logroscino   +9 more
wiley   +1 more source

Spatial Analysis of Seasonal Precipitation over Iran: Co-Variation with Climate Indices

ISPRS International Journal of Geo-Information, 2020
Temporary changes in precipitation may lead to sustained and severe drought or massive floods in different parts of the world. Knowing the variation in precipitation can effectively help the water resources decision-makers in water resources management ...
Majid Dehghani, Somayeh Salehi, Amir Mosavi, Narjes Nabipour, Shahaboddin Shamshirband, Pedram Ghamisi   +5 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Is Bias Correction in Dynamical Downscaling Defensible?

Geophysical Research Letters
Localized projections of 21st‐century hydroclimate variables obtained from downscaling Global Climate Model (GCM) output are central to informing regional impact assessments and infrastructure planning.
Mark D. Risser, Stefan Rahimi, Naomi Goldenson, Alex Hall, Zachary J. Lebo, Daniel R. Feldman   +5 more
doaj   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Unique Temperature Trend Pattern Associated With Internally Driven Global Cooling and Arctic Warming During 1980–2022

Geophysical Research Letters
Diagnosing the role of internal variability over recent decades is critically important for both model validation and projections of future warming. Recent research suggests that for 1980–2022 internal variability manifested as Global Cooling and Arctic ...
Aodhan J. Sweeney, Qiang Fu, Stephen Po‐Chedley, Hailong Wang, Muyin Wang   +4 more
doaj   +1 more source

A Strategy to set up Test Dataset and Evaluation Benchmark for Radar Nowcasting of Precipitation in Italy

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Prediction of extreme precipitation with high spatial resolution on short time scales (i.e., nowcasting) is still challenging, and data-driven approaches such as artificial intelligence tools are increasingly being used.
Clizia Annella, Edoardo Raparelli, Gianfranco Vulpiani, Vincenzo Capozzi, Elisa Adirosi, Luca Baldini, Giorgio Budillon, Raffaele Lidori, Mario Montopoli   +8 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source