Results 51 to 60 of about 15,738,050 (291)

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Early Development and Tuning of a Global Coupled Cloud Resolving Model, and its Fast Response to Increasing CO2

Tellus: Series A, Dynamic Meteorology and Oceanography, 2022
Since the dawn of functioning numerical dynamical atmosphere- and ocean models, their resolution has steadily increased, fed by an exponential growth in computational capabilities.
Thorsten Mauritsen, Rene Redler, Monika Esch, Bjorn Stevens, Cathy Hohenegger, Daniel Klocke, Renate Brokopf, Helmuth Haak, Leonidas Linardakis, Niklas Röber, Reiner Schnur   +10 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Large near-term projected snowpack loss over the western United States

Nature Communications, 2017
Mountain snowpack in the western United States has declined over the past three decades. Fyfeet al. show that this trend cannot be explained by natural variability alone and show that under a business-as-usual scenario a further loss of up to 60% in ...
John C. Fyfe, Chris Derksen, Lawrence Mudryk, Gregory M. Flato, Benjamin D. Santer, Neil C. Swart, Noah P. Molotch, Xuebin Zhang, Hui Wan, Vivek K. Arora, John Scinocca, Yanjun Jiao   +11 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Desertification Mitigation in Northern China Was Promoted by Climate Drivers after 2000

Remote Sensing
Desertification greatly threatens the ecological environment and sustainable development over approximately 30% of global land. In this study, the contributions of climate drivers and human activity in shaping the desertification process from 1984 to ...
Haohui Li, Kai Yang, Yang Cui, Lingyun Ai, Chenghai Wang, Zhenting Wang, Caixia Zhang   +6 more
doaj   +1 more source

A Diagnostic PDF Cloud Scheme to Improve Subtropical Low Clouds in NCAR Community Atmosphere Model (CAM5)

Journal of Advances in Modeling Earth Systems, 2018
Low clouds strongly impact the radiation budget of the climate system, but their simulation in most GCMs has remained a challenge, especially over the subtropical stratocumulus region.
Yi Qin, Yanluan Lin, Shiming Xu, Hsi‐Yen Ma, Shaocheng Xie   +4 more
doaj   +1 more source

Cloud Computing for Climate Modelling: Evaluation, Challenges and Benefits

Computers, 2020
Cloud computing is a mature technology that has already shown benefits for a wide range of academic research domains that, in turn, utilize a wide range of application design models.
Diego Montes , Juan A. Añel , David C. H. Wallom , Peter Uhe , Pablo V. Caderno, Tomás F. Pena   +5 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Summer monsoon precipitation patterns and their relationship to flood probabilities across Pakistan

Journal of Hydrology: Regional Studies
Study region: In Pakistan, the climate crisis manifests most dangerously through extreme monsoon precipitation and subsequent flooding. Study focus: To quantify the relationship between summer monsoon precipitation and flood probability, the study ...
Mohib Ullah, Chenghai Wang, Safi Ullah, Esha Malik, Mushtaq Ahmad Jan, Ali Naqi   +5 more
doaj   +1 more source