Results 41 to 50 of about 16,458,636 (253)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Future changes in fog frequency from the UKCP09 ensemble of regional climate model projections [PDF]

, 2010
This report describes projections of the frequency of occurrence of fog derived from the UK Climate Projections 2009 (UKCP09) 11 member Regional Climate Model (RCM) simulations run at a 25 km resolution.
Murphy, James, Boorman, Penelope, Jenkins, Geoff   +2 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Early Development and Tuning of a Global Coupled Cloud Resolving Model, and its Fast Response to Increasing CO2

Tellus: Series A, Dynamic Meteorology and Oceanography, 2022
Since the dawn of functioning numerical dynamical atmosphere- and ocean models, their resolution has steadily increased, fed by an exponential growth in computational capabilities.
Thorsten Mauritsen, Rene Redler, Monika Esch, Bjorn Stevens, Cathy Hohenegger, Daniel Klocke, Renate Brokopf, Helmuth Haak, Leonidas Linardakis, Niklas Röber, Reiner Schnur   +10 more
doaj   +1 more source

Seasonal Climate Forecasts and Risk Management Among Georgia Farmers [PDF]

, 2008
Recent increases in the scientific robustness of seasonal climate forecasts have not led to substantial changes in farmers’ risk management strategies of actors, largely because there is poor integration of scientific forecasting into farmers’ decision ...
Hoogenhoom, G., Broad, K., Breuer, N.E, Paz, J., Ingram, K.T, Roncoli, C., Ingram, K.T., Crane, T.A, Breuer, N.E., Crane, T.A., Broad, K, Roncoli, C, Hoogenhoom, G, Paz, J   +13 more
core  

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Large near-term projected snowpack loss over the western United States

Nature Communications, 2017
Mountain snowpack in the western United States has declined over the past three decades. Fyfeet al. show that this trend cannot be explained by natural variability alone and show that under a business-as-usual scenario a further loss of up to 60% in ...
John C. Fyfe, Chris Derksen, Lawrence Mudryk, Gregory M. Flato, Benjamin D. Santer, Neil C. Swart, Noah P. Molotch, Xuebin Zhang, Hui Wan, Vivek K. Arora, John Scinocca, Yanjun Jiao   +11 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Desertification Mitigation in Northern China Was Promoted by Climate Drivers after 2000

Remote Sensing
Desertification greatly threatens the ecological environment and sustainable development over approximately 30% of global land. In this study, the contributions of climate drivers and human activity in shaping the desertification process from 1984 to ...
Haohui Li, Kai Yang, Yang Cui, Lingyun Ai, Chenghai Wang, Zhenting Wang, Caixia Zhang   +6 more
doaj   +1 more source

A Diagnostic PDF Cloud Scheme to Improve Subtropical Low Clouds in NCAR Community Atmosphere Model (CAM5)

Journal of Advances in Modeling Earth Systems, 2018
Low clouds strongly impact the radiation budget of the climate system, but their simulation in most GCMs has remained a challenge, especially over the subtropical stratocumulus region.
Yi Qin, Yanluan Lin, Shiming Xu, Hsi‐Yen Ma, Shaocheng Xie   +4 more
doaj   +1 more source