Results 41 to 50 of about 293,074 (268)

Climate Change and Climate Modeling

Eos, Transactions American Geophysical Union, 2011
In long‐established fields like fluid mechanics or quantum theory, the contents of introductory textbooks are mostly predictable: The basics are covered in more or less the same order, and while cutting‐edge research occasionally gets a look‐in (depending on the inclinations of the authors), the contents are far more frequently reworkings of previous ...
openaire   +2 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Understanding the El Niño Southern Oscillation Effect on Cut-Off Lows as Simulated in Forced SST and Fully Coupled Experiments

Atmosphere, 2022
In this study, we show that changes in the 250 hPa vorticity cut-off low (COL) activity may possibly be driven by sea surface temperature (SST) variations in the tropical Pacific.
Henri R. Pinheiro, Tercio Ambrizzi, Kevin I. Hodges, Manoel A. Gan   +3 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

A Synergistic Approach for Evaluating Climate Model Output for Ecological Applications

Frontiers in Marine Science, 2017
Increasing concern about the impacts of climate change on ecosystems is prompting ecologists and ecosystem managers to seek reliable projections of physical drivers of change.
Rachel D. Cavanagh, Eugene J. Murphy, Thomas J. Bracegirdle, John Turner, Cheryl A. Knowland, Stuart P. Corney, Walker O. Smith, Claire M. Waluda, Nadine M. Johnston, Richard G. J. Bellerby, Richard G. J. Bellerby, Andrew J. Constable, Andrew J. Constable, Daniel P. Costa, Eileen E. Hofmann, Jennifer A. Jackson, Iain J. Staniland, Dieter Wolf-Gladrow, José C. Xavier, José C. Xavier   +19 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Attribution of extreme rainfall from Hurricane Harvey, August 2017

Environmental Research Letters, 2017
During August 25–30, 2017, Hurricane Harvey stalled over Texas and caused extreme precipitation, particularly over Houston and the surrounding area on August 26–28. This resulted in extensive flooding with over 80 fatalities and large economic costs.
Geert Jan van Oldenborgh, Karin van der Wiel, Antonia Sebastian, Roop Singh, Julie Arrighi, Friederike Otto, Karsten Haustein, Sihan Li, Gabriel Vecchi, Heidi Cullen   +9 more
doaj   +1 more source

Constraining CMIP6 estimates of Arctic Ocean temperature and salinity in 2025-2055

Frontiers in Marine Science, 2023
Global climate models (CMIP6 models) are the basis for future predictions and projections, but these models typically have large biases in their mean state of the Arctic Ocean.
Helene Reinertsen Langehaug, Hanne Sagen, A. Stallemo, Petteri Uotila, L. Rautiainen, Steffen Malskær Olsen, Marion Devilliers, Shuting Yang, E. Storheim   +8 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source