Results 61 to 70 of about 1,748,129 (280)
Risk and reward of the global truffle sector under predicted climate change
Environmental Research Letters, 2022 Climate change has been described as the main threat for the cultivation and growth of truffles, but hydroclimate variability and model uncertainty challenge regional projections and adaptation strategies of the emerging sector.
Tomáš Čejka +7 more
doaj +1 more source
Cenozoic paleoceanography 1986: An introduction [PDF]
, 1987 New developments in Cenozoic paleoceanography include the application of climate models and atmospheric general circulation models to questions of climate reconstruction, the refinement of conceptual models for interpretation of the carbon isotope record
Arthur +44 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Журнал Белорусского государственного университета: География, геология, 2019 Long-term changes in air temperature on the territory of the Republic of Tatarstan in the 20th–21st centuries are considered. The periods of unambiguous changes in the surface air temperature are determined.
Yuri P. Perevedentsev +3 more
doaj +1 more source
Carbon Dioxide Uptake by Mortars and Concretes Made with Portuguese Cements
Applied Sciences, 2020 As the cement industry continues to address its role in the climate crisis, Portugal’s cement industry has started to calculate its net CO2 emissions to become an entirely carbon neutral sector.
Miguel Ángel Sanjuán +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Detection of Forced Change Within Combined Climate Fields Using Explainable Neural Networks
Journal of Advances in Modeling Earth Systems, 2022 Assessing forced climate change requires the extraction of the forced signal from the background of climate noise. Traditionally, tools for extracting forced climate change signals have focused on one atmospheric variable at a time, however, using ...
Jamin K. Rader +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The surface impacts of Arctic stratospheric ozone anomalies
Environmental Research Letters, 2014 In the Arctic stratosphere, total column ozone in the spring can vary, from year to year, by as much as 30%. This large interannual variability, however, is absent from many present-generation climate models, in which the prescribed seasonal cycle of ...
K L Smith, L M Polvani
doaj +1 more source