Results 101 to 110 of about 471,024 (280)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effect of Long-Term Climbing Training on Cerebellar Ataxia: A Case Series [PDF]
, 2011 Stephan Marianne Anke +6 more
openalex +1 more source
The Problem of Adhesion Methods and Locomotion Mechanism Development for Wall-Climbing Robots
, 2019 This review considers a problem in the development of mobile robot adhesion methods with vertical surfaces and the appropriate locomotion mechanism design.
Bykov, Nikita V., Vlasova, Nataly S.
core
Modern mechanisms make manless Martian mission mobile: Spin-off spells stairclimbing self-sufficiency for earthbound handicapped [PDF]
, 1975 Concepts were developed for three wheel chairs from progressively improving designs of a proposed unmanned roving vehicle for the surface exploration of Mars; as a spin-off, a concept for a stair-climbing wheel chair was generated.
Hassel, D. R. +2 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
, 2014 Encouraging and mentoring young minds, consistently finding new ways to use her love of climbing and adventure to promote character and leadership development, and always ready for the next big challenge, Ally Siegel ’16 fearlessly pushes herself to ...
Siegel, Alexandra M.
core
GALR1/GALR2 Knockdown rats block the Depression and Anxiogenic effects induced by GAL(1-15): The Heterodimer GALR1/GALR2 as a target of GAL(1-15). [PDF]
, 2015 Comunicación OralThe Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) and Open Field ...
Borroto-Escuela, Dasiel +8 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Abdominal pain with fever, two cousins with same presentation
Mediterranean Journal of Hematology and Infectious Diseases, 2014 Two young men whom were cousin referred to our hospital because of severe abdominal pain ,started after mountain climbing over 2500 meter height . The pain was severe and so they were not able to continue and had to come back.
Shahram habibzadeh +3 more
doaj
An introduction to Animal Frontiers: The uphill climb [PDF]
, 2011 Meghan Wulster-Radcliffe, Steven A Zinn
openalex +1 more source