Results 81 to 90 of about 457,059 (295)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Commentary: Supporting Maternal Mental Health and Nurturing Care in Humanitarian Settings
Journal on Education in Emergencies, 2021 Bernadette Daelmans +5 more
doaj +1 more source
Climbing the cosmic ladder with stellar twins
, 2015 Distances to stars are key to revealing a three-dimensional view of the Milky Way, yet their determination is a major challenge in astronomy. Whilst the brightest nearby stars benefit from direct parallax measurements, fainter stars are subject of ...
Casey, A. +5 more
core +3 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Cracks in the Climb: Health Problems Faced in Bouldering
Quality in SportBouldering is a distinctive discipline within the broader realm of climbing sports, characterized by its dynamic nature and the absence of ropes, which leads to a higher frequency of falls. This climbing style has seen a surge in global popularity, with
Michał Szymchel +5 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Phyllomedusa: Journal of Herpetology, 2007 The endangered Panamanian golden frog, Atelopus zeteki, is a stream dweller of middle elevation rain forests of the Panamanian isthmus. In order to better understand this species for conservation, we set out to determine the nocturnal whereabouts of this
Erik D. Lindquist +4 more
doaj
Frontiers in Physiology, 2018 Objectives: To evaluate the immediate responses to forearm compression of blood lactate concentration, heart rate, perceived exertion and local forearm muscle pain during severe climbing in elite climbers.Method: Seven elite climbers (18 ± 2 years; 164 ±
Florian Azad Engel +6 more
doaj +1 more source
Articulated elastic-loop roving vehicles [PDF]
, 1973 Prototype vehicle features exceptional obstacle-negotiating and slope-climbing capabilities plus high propulsive efficiency. Concept should interest designers of polar or ocean-bottom research vehicles.
Chang, C. J., Trautwein, W.
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source