Results 61 to 70 of about 146,241 (297)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Virtual climbing: climb in place with four limbs
Frontiers in Virtual RealityThis paper presents the development of a virtual climbing application using commercially available virtual reality (VR) equipment. The application enables users to simulate climbing a virtual wall with their hands and feet while remaining physically grounded.
Takashi Mitsuda, Shoichi Kimura
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Learning Climbing Controllers for Physics‐Based Characters
Despite the growing demand for capturing diverse motions, collecting climbing motion data remains challenging due to difficulties in tracking obscured markers and scanning climbing structures.
Kwon, Taesoo +2 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
POTENTIAL IMPACTS OF THE ASIAN CLIMBING PERCH ON QUEENSLAND [PDF]
Risk of establishment of the freshwater climbing perch (Anabas testudineus) in mainland Queensland from the Torres Strait is high. The species is dispersed through human assistance and/or attributes that assist its own spread.
Micke, Wade, East, Miriam
core
Psychophysiological and emotional antecedents of climbing performance [PDF]
, 2017 Recreational sport climbing is characterised by self-selected route choices, which place participants under both physiological and psychological stress.
Giles, David
core +1 more source
Work hands and feet in motion on the vertical ladder into the prosthesis disabled lower limb [PDF]
Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012 The influence of the conditions of ascent and descent on the stairs with disabilities is shown. The study involved 12 persons with lower limb prosthetic right or left foot.
Li Yugang, Ma Haozhe, Chen Jian, Xia Yu
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source